Expression, regulation and function of miR-126 in the mouse choroid vasculature.
Expression, regulation and function of miR-126 in the mouse choroid vasculature.
复制标题
DOI：
10.1016/j.exer.2018.02.026
复制
发表时间：
2018-05
影响因子：
3.4
通讯作者：
Wang S
中科院分区：
文献类型：
--
作者：
Zhao F;Anderson C;Karnes S;Zhou Q;Ma J;Jin ZG;Bhattacharjee PS;Wang S
MicroRNA miR-126 has been shown to be required for proper angiogenesis in several models. However, its expression, regulation and function in the mouse choroid remain unclear. Our previous data has shown that miR-126 expression is enriched in the endothelial cells (ECs) of the mouse choroid. Here we report that a 5.5 kb Egfl7/miR-126 promoter drives the expression of miR-126 in the choroid ECs during choroidal vascular development. The expression of miR-126 in the ECs is regulated by flow stress likely through Krüppel-like transcriptional factors. miR-126−/− mice show mildly delayed choroidal vascular development, but adult knockout mice develop periphery choroidal vascular lesions. This study suggests that miR-126 is largely dispensable for mouse choroidal development but required for maintaining choroidal vasculature integrity.
登录
查看更多内容
影响因子：
17.8
作者：
Nickla, Debora L.;Wallman, Josh
通讯作者：
Wallman, Josh
影响因子：
4
作者：
Wang, Shusheng;Olson, Eric N.
通讯作者：
Olson, Eric N.
影响因子：
11.8
作者：
Lee, John S.;Yu, Cing;Kahn, Mark L.
通讯作者：
Kahn, Mark L.
影响因子：
4.4
作者：
McLeod DS;Grebe R;Bhutto I;Merges C;Baba T;Lutty GA
通讯作者：
Lutty GA
影响因子：
20.3
作者：
Dekker, RJ;van Soest, S;Horrevoets, AJG
通讯作者：
Horrevoets, AJG