MSCs and Inflammatory Cells Crosstalk in Regenerative Medicine: Concerted Actions for Optimized Resolution Driven by Energy Metabolism.
MSCs and Inflammatory Cells Crosstalk in Regenerative Medicine: Concerted Actions for Optimized Resolution Driven by Energy Metabolism.
复制标题
再生医学中的间充质干细胞和炎症细胞的串扰：由能量代谢驱动的优化解决方案的协同行动。
DOI：
10.3389/fimmu.2021.626755
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发表时间：
2021
影响因子：
7.3
通讯作者：
Casteilla L
中科院分区：
文献类型：
--
作者：
Planat-Benard V;Varin A;Casteilla L
间充质基质细胞（Mesenchymal stromal cells，MSCs）因其在控制患者炎症状态方面的显著功效而被广泛应用于基于细胞的治疗。尽管最近的进展和令人鼓舞的结果，不恒定的治疗效益的报告表明，在理解MSC的免疫调节作用机制的重大突破仍有待调查，当然从原来的观点理解。本文就骨髓间充质干细胞与天然免疫区室（粒细胞和髓细胞）的密切关系作一综述。本文还将讨论细胞间的通讯机制，如因子分泌、细胞间接触、细胞外囊泡、线粒体转运和胞浆细胞增多等。将讨论支持其在临床环境中的部分治疗效果的MSC的免疫样特性，以及它们的潜力（免疫调节，抗菌，抗炎，抗氧化防御和代谢适应......）和介导的影响，如细胞极化，分化，死亡和存活在触发组织再生的各种免疫和组织细胞靶点决定因素。它们在感测、反应和产生影响组织炎症的代谢物方面的代谢特性将被强调。该综述最终将开放讨论如何将正在进行的MSC科学进展有效地转化为慢性和年龄相关炎症性疾病的临床，以及目前仍有待克服的限制和差距，以实现组织再生和年轻化。
Mesenchymal stromal cells (MSCs) are currently widely used in cell based therapy regarding to their remarkable efficacy in controlling the inflammatory status in patients. Despite recent progress and encouraging results, inconstant therapeutic benefits are reported suggesting that significant breakthroughs in the understanding of MSCs immunomodulatory mechanisms of action remains to be investigated and certainly apprehended from original point of view. This review will focus on the recent findings regarding MSCs close relationship with the innate immune compartment, i.e. granulocytes and myeloid cells. The review will also consider the intercellular mechanism of communication involved, such as factor secretion, cell-cell contact, extracellular vesicles, mitochondria transfer and efferocytosis. Immune-like-properties of MSCs supporting part of their therapeutic effect in the clinical setting will be discussed, as well as their potentials (immunomodulatory, anti-bacterial, anti-inflammatory, anti-oxidant defenses and metabolic adaptation…) and effects mediated, such as cell polarization, differentiation, death and survival on various immune and tissue cell targets determinant in triggering tissue regeneration. Their metabolic properties in term of sensing, reacting and producing metabolites influencing tissue inflammation will be highlighted. The review will finally open to discussion how ongoing scientific advances on MSCs could be efficiently translated to clinic in chronic and age-related inflammatory diseases and the current limits and gaps that remain to be overcome to achieving tissue regeneration and rejuvenation.
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影响因子：
7.7
作者：
Cani, Patrice D.;Amar, Jacques;Burcelin, Remy
通讯作者：
Burcelin, Remy
影响因子：
29.4
作者：
Abraham C;Dulai PS;Vermeire S;Sandborn WJ
通讯作者：
Sandborn WJ
影响因子：
3.8
作者：
Bahroudi, Mahboube;Bakhshi, Bita;Najar-peerayeh, Shahin
通讯作者：
Najar-peerayeh, Shahin
影响因子：
8.8
作者：
Chinnadurai R;Rajan D;Qayed M;Arafat D;Garcia M;Liu Y;Kugathasan S;Anderson LJ;Gibson G;Galipeau J
通讯作者：
Galipeau J
影响因子：
5.9
作者：
Chinnadurai, Raghavan;Garcia, Marco A.;Sakurai, Yumiko;Lam, Wilbur A.;Kirk, Allan D.;Galipeau, Jacques;Copland, Ian B.
通讯作者：
Copland, Ian B.