Mutations and Evolution of the SARS-CoV-2 Spike Protein.
Mutations and Evolution of the SARS-CoV-2 Spike Protein.
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DOI：
10.3390/v14030640
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发表时间：
2022-03-19
期刊：
影响因子：
--
通讯作者：
Huang W
中科院分区：
文献类型：
--
作者：
Magazine N;Zhang T;Wu Y;McGee MC;Veggiani G;Huang W
SARS-CoV-2 刺突蛋白介导目标识别、细胞进入，并最终介导导致不同程度的 COVID-19 严重程度的病毒感染。刺突蛋白内突变的正向进化选择导致了新的 SARS-CoV-2 变体的出现，其整体适应性大大增强。鉴于刺突蛋白改变导致变异体适应性增强的趋势，科学界了解这些突变改变病毒功能的机制至关重要。截至 2022 年 3 月，世界卫生组织将 5 种 SARS-CoV-2 毒株标记为“值得关注的变种”：Alpha、Beta、Gamma、Delta 和 Omicron 变种。这篇综述总结了这些菌株中发生的刺突蛋白常见突变增强其各自变体整体适应性的潜在机制。在 SARS-CoV-2 刺突蛋白结构、刺突/受体结合界面、刺突/抗体结合和病毒中和的背景下解决这些突变时，我们总结了可用于估计未来突变对 SARS-CoV-2 进化的影响的一般范式。
The SARS-CoV-2 spike protein mediates target recognition, cellular entry, and ultimately the viral infection that leads to various levels of COVID-19 severities. Positive evolutionary selection of mutations within the spike protein has led to the genesis of new SARS-CoV-2 variants with greatly enhanced overall fitness. Given the trend of variants with increased fitness arising from spike protein alterations, it is critical that the scientific community understand the mechanisms by which these mutations alter viral functions. As of March 2022, five SARS-CoV-2 strains were labeled “variants of concern” by the World Health Organization: the Alpha, Beta, Gamma, Delta, and Omicron variants. This review summarizes the potential mechanisms by which the common mutations on the spike protein that occur within these strains enhance the overall fitness of their respective variants. In addressing these mutations within the context of the SARS-CoV-2 spike protein structure, spike/receptor binding interface, spike/antibody binding, and virus neutralization, we summarize the general paradigms that can be used to estimate the effects of future mutations along SARS-CoV-2 evolution.
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DOI：
10.33696/immunology.3.085
发表时间：
2021
期刊：
Journal of cellular immunology
影响因子：
--
作者：
Ostrov DA
通讯作者：
Ostrov DA
影响因子：
16.6
作者：
Cattin-Ortolá J;Welch LG;Maslen SL;Papa G;James LC;Munro S
通讯作者：
Munro S
SARS-COV-2尖峰的融合肽重新排列到插入双层胶束的楔形物中。
影响因子：
15
作者：
Koppisetti RK;Fulcher YG;Van Doren SR
通讯作者：
Van Doren SR
影响因子：
8.8
作者：
Meng B;Kemp SA;Papa G;Datir R;Ferreira IATM;Marelli S;Harvey WT;Lytras S;Mohamed A;Gallo G;Thakur N;Collier DA;Mlcochova P;COVID-19 Genomics UK (COG-UK) Consortium;Duncan LM;Carabelli AM;Kenyon JC;Lever AM;De Marco A;Saliba C;Culap K;Cameroni E;Matheson NJ;Piccoli L;Corti D;James LC;Robertson DL;Bailey D;Gupta RK
通讯作者：
Gupta RK
影响因子：
6
作者：
Klinakis A;Cournia Z;Rampias T
通讯作者：
Rampias T