Interactions of plasmalogens and their diacyl analogs with singlet oxygen in selected model systems.
Interactions of plasmalogens and their diacyl analogs with singlet oxygen in selected model systems.
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DOI：
10.1016/j.freeradbiomed.2011.01.002
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发表时间：
2011-04-01
影响因子：
7.4
通讯作者：
Sarna, Tadeusz
中科院分区：
文献类型：
--
作者：
Broniec, Agnieszka;Klosinski, Radoslaw;Pawlak, Anna;Wrona-Krol, Marta;Thompson, David;Sarna, Tadeusz
关键词：
Plasmalogens (Plg) are phospholipids containing vinyl ether linkage at the sn-1 position of the glycerophospholipid backbone. In spite of being quite abundant in humans, the biological role of plasmalogens remains speculative. It has been postulated that plasmalogens are physiological antioxidants with the vinyl ether functionality serving as sacrificial trap for free radicals and singlet oxygen. However, no quantitative data on the efficiency of plasmalogens to scavenge these reactive species are available. In this study, rate constants of quenching of singlet oxygen, generated by photosensitized energy transfer, by several plasmalogens and, for comparison, by their diacyl analogs, were determined by time-resolved detection of phosphorescence at 1270 nm. Relative rates of the interaction of singlet oxygen, with plasmalogens and other lipids in solution and liposomal membranes were measured by electron paramagnetic resonance oximetry and product analysis, employing HPLC-EC detection of cholesterol hydroperoxides and iodometric assay of lipid hydroperoxides. Results show that singlet oxygen interacts with plasmalogens significantly faster than with the other lipids, with he corresponding rate constants being by one-two orders of magnitude greater. The quenching of singlet oxygen by plasmalogens is mostly reactive in nature and results from its preferential interaction with the vinyl ether bond. The data suggest that plasmalogens could protect unsaturated membrane lipids against oxidation induced by singlet oxygen, providing that the oxidation products are not excessively cytotoxic.
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影响因子：
15
作者：
Lambert, CR;Kochevar, IE
通讯作者：
Kochevar, IE
影响因子：
1.9
作者：
FOGLIA, TA;NUNGESSER, E;MARMER, WN
通讯作者：
MARMER, WN
DOI：
10.1016/0005-2760(80)90113-7
发表时间：
1980-01-01
期刊：
BIOCHIMICA ET BIOPHYSICA ACTA
影响因子：
--
作者：
HANAHAN, DJ;JOSEPH, M;MORALES, R
通讯作者：
MORALES, R
影响因子：
3.4
作者：
Acar, Niyazi;Gregoire, Stephane;Bretillon, Lionel
通讯作者：
Bretillon, Lionel
影响因子：
15
作者：
FRIMER, AA;BARTLETT, PD;JEWETT, JG
通讯作者：
JEWETT, JG