Elevated Plasma Levels of Chemerin in Newly Diagnosed Type 2 Diabetes Mellitus With Hypertension
Elevated Plasma Levels of Chemerin in Newly Diagnosed Type 2 Diabetes Mellitus With Hypertension
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新诊断的 2 型糖尿病伴高血压患者血浆 Chemerin 水平升高
DOI：
10.2310/jim.0b013e3181ec5db2
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发表时间：
2010-10
影响因子：
2.6
通讯作者：
Li, Ling
中科院分区：
文献类型：
--
作者：
Yang, Mengliu;Yang, Gangyi;Dong, Jing;Liu, Ying;Zong, Haihong;Liu, Hua;Boden, Guenther;Li, Ling
Chemerin是最近发现的一种代谢调节激素。这种激素在人类中的病理生理作用仍然未知。在这项研究中，我们比较了血浆chemerin水平的2型糖尿病患者或不伴高血压和对照组。我们还评估了这些受试者血浆chemerin与身体组成和代谢参数的相关性。2型糖尿病合并高血压患者血浆chemerin水平明显高于2型糖尿病患者和正常对照组（P < 0.01）。多元回归分析显示腰围、舒张压、糖负荷后2 h血浆胰岛素、HbA1c是影响血浆chemerin水平的独立相关因素。目前的工作表明chemerin与胰岛素抵抗，肥胖和代谢综合征的发病机制的潜在联系。
Chemerin is a recently discovered metabolic regulator hormone. The pathophysiologic role of this hormone in humans remains unknown. In this study, we have compared plasma chemerin levels in patients with type 2 diabetes mellitus with or without hypertension and in control subjects. We also assessed the association of plasma chemerin with body composition and metabolic parameters in these subjects. Plasma chemerin levels were found to be markedly increased in patients with type 2 diabetes mellitus with hypertension as compared with patients with type 2 diabetes mellitus and normal controls (P < 0.01). Multiple regression analysis showed that waist circumference, diastolic blood pressure, 2-hour plasma insulin after glucose overload, and HbA1c were independently related factors influencing plasma chemerin levels. The present work indicates the potential link of chemerin with the pathogenesis of insulin resistance, obesity, and metabolic syndrome.
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影响因子：
4.9
作者：
J. Chalmers;B. Neal
通讯作者：
J. Chalmers;B. Neal
影响因子：
15.9
作者：
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通讯作者：
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影响因子：
8.2
作者：
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通讯作者：
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4.8
作者：
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通讯作者：
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DOI：
10.1016/j.bbrc.2007.08.104
发表时间：
2007-11-03
影响因子：
3.1
作者：
Roh, Sang-Gun;Song, Sang-Houn;Sasaki, Shin-ichi
通讯作者：
Sasaki, Shin-ichi