Common properties for propargylamines of enhancing superoxide dismutase and catalase activities in the dopaminergic system in the rat: implications for the life prolonging effect of (-)deprenyl.
Common properties for propargylamines of enhancing superoxide dismutase and catalase activities in the dopaminergic system in the rat: implications for the life prolonging effect of (-)deprenyl.
复制标题
炔丙胺增强大鼠多巴胺能系统超氧化物歧化酶和过氧化氢酶活性的共同特性：对 (-)deprenyl 延长寿命作用的影响。
DOI：
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发表时间：
2000
期刊：
影响因子：
--
通讯作者：
M. Carrillo
中科院分区：
文献类型：
--
作者：
K. Kitani;C. Minami;W. Maruyama;S. Kanai;G. Ivy;M. Carrillo
据报道，(-)丙炔苯丙胺可以延长不同动物物种的寿命。此外，该药物还能有效提高大脑多巴胺能区域的抗氧化酶活性，例如超氧化物歧化酶（SOD）和过氧化氢酶（CAT）。我们发现药物对抗氧化酶活性的影响是高度剂量依赖性的，随着剂量的增加而增加，然而，较高的剂量变得效果较差，过量的剂量变得相反。最重要的是，效果的最佳剂量根据动物种类、品系、性别、年龄和治疗持续时间的不同而有很大差异，这至少可以部分解释过去不同研究报告的差异。从该药物在延长寿命和增加内源性抗氧化酶活性之间的量效关系的平行性来看，我们认为(-)丙肾上腺素的上述两种作用可能存在因果关系。这篇综述总结了我们过去的一系列研究，并报告了我们最近的观察结果，即其他丙炔胺如雷沙吉兰和 (R)-N-(2-庚基)-N-甲基丙酰胺 (R-2HMP) 也具有增强抗氧化酶活性的特性。此外，我们最近的研究发现，这些炔丙胺不仅可以增加大脑多巴胺能区域的抗氧化酶活性，还可以增加大脑外多巴胺能组织（例如心脏和肾脏）的抗氧化酶活性。这些观察结果与过去报道的 (-)丙肾上腺素的延长寿命作用有关。
(-)Deprenyl has been reported to prolong the life span of different animal species. Further, the drug effectively increases antioxidant enzyme activities such as superoxide dismutase (SOD) and catalase (CAT) in brain dopaminergic regions. We have found that the effect of the drug on antioxidant enzyme activities is highly dose dependent, increasing with an increasing dose, however, a higher dose becomes less effective and an excessive dose becomes adversely effective. Most importantly, an optimal dose for the effect varies widely depending on animal species, strain, sex, age and duration of the treatment, which may at least partly explain discrepancies reported among different studies in the past. From the parallelism of the dose-effect relationship of the drug between life span extension and increasing endogenous antioxidant enzyme activity, we have suggested that the above two effects of (-)deprenyl may be causally related. This review summarizes our past series of studies and also reports our very recent observation that other propargylamines such as rasagiline and (R)-N-(2-heptyl)-N-methylpropagylamine (R-2HMP) also share the property of enhancing antioxidant enzyme activities. Further, our most recent study has found that these propargylamines increase antioxidant enzyme activities not only in brain dopaminergic regions but in extra-brain dopaminergic tissues such as the heart and kidneys. These observations are discussed in relation to the life prolonging effect of (-)deprenyl reported in the past.
Deprenyl 重新启动动情周期，降低血清催乳素，并降低老年无周期大鼠的乳腺和垂体肿瘤的发生率。
DOI：
10.1210/endo.136.3.7867565
发表时间：
1995
期刊：
Endocrinology.
影响因子：
--
作者：
Thyagarajan,S;Meites,J;Quadri,SK
通讯作者：
Quadri,SK
L-丙炔苯丙胺对致癌物诱发的乳腺肿瘤大鼠的抗肿瘤作用。
影响因子：
9.7
作者：
ThyagaRajan,S;Felten,SY;Felten,DL
通讯作者：
Felten,DL