Antitumor effect of L-deprenyl in rats with carcinogen-induced mammary tumors.
Antitumor effect of L-deprenyl in rats with carcinogen-induced mammary tumors.
复制标题
L-丙炔苯丙胺对致癌物诱发的乳腺肿瘤大鼠的抗肿瘤作用。
DOI：
10.1016/s0304-3835(97)00431-x
复制
发表时间：
1998
期刊：
影响因子：
9.7
通讯作者：
Felten,DL
中科院分区：
文献类型：
--
作者：
ThyagaRajan,S;Felten,SY;Felten,DL
丙炔苯丙胺是一种单胺氧化酶-B（MAO-B）抑制剂，具有广泛的药理学特性，在治疗人类神经退行性疾病方面具有治疗益处。最近的研究表明，丙炔苯丙胺具有神经保护功能，这是不依赖于它的单胺氧化酶-B抑制活性。本研究的重点是探讨是否长期处理年轻的Sprague-Dawley雌性大鼠与Deprenyl之前和之后9，10-二甲基-1，2-苯并蒽（DMBA）管理将抑制乳腺肿瘤的发展，通过施加神经保护作用的结节漏斗多巴胺（TIDA）神经元在内侧基底下丘脑（MBH）。为此，在治疗期结束时，通过高效液相色谱法（HPLC）测定MBH中的儿茶酚胺、吲哚胺及其代谢产物的浓度。雌性Sprague-Dawley大鼠（28-29日龄）经腹腔注射生理盐水或0.25或2.5 mg丙炔苯丙胺/kg b.w.每日一次，持续4周，然后施用DMBA。在施用DMBA之后，每天用盐水或丙炔苯丙胺处理大鼠，持续27周。在治疗期结束时，在DMBA给药前后接受2.5 mg/kg丙炔苯丙胺的大鼠中以及在DMBA给药后接受2.5 mg/kg丙炔苯丙胺治疗的大鼠中，肿瘤发生率和肿瘤数量显著降低。在31周的整个治疗期间，用0.25 mg/kg丙炔苯丙胺治疗的大鼠的肿瘤数量也显著减少。在整个给药期间，体重增加，组间无显著差异。DMBA给药后和整个给药期间用2.5 mg Deprenyl处理大鼠，导致MBH中去甲肾上腺素（NE）、多巴胺（DA）和5-羟色胺（5-HT）代谢产物浓度显著降低，但MBH中NE、DA和5-HT浓度无显著变化。这些结果表明，丙炔苯丙胺的管理阻断乳腺肿瘤的发展，部分通过抑制代谢的儿茶酚胺和吲哚胺，并可能通过赋予神经保护作用的TIDA神经元的MBH，特别是在0.25毫克/公斤丙炔苯丙胺。
Deprenyl, a monoamine oxidase-B (MAO-B) inhibitor, has a wide range of pharmacological properties that are beneficial therapeutically in the treatment of human neurodegenerative diseases. Recent studies have demonstrated that deprenyl possesses a neuroprotective function that is not dependent on its MAO-B inhibitory activity. The focus of the present study was to investigate whether prolonged treatment of young Sprague–Dawley female rats with deprenyl before and after 9,10-dimethyl-1,2-benzanthracene (DMBA) administration would inhibit the development of mammary tumors by exerting a neuroprotective effect on the tuberoinfundibular dopaminergic (TIDA) neurons in the medial basal hypothalamus (MBH). For this purpose, the concentrations of catecholamines, indoleamine and their metabolites were measured in the MBH by high-performance liquid chromatography (HPLC) at the end of the treatment period. Female Sprague–Dawley rats (28–29 days old) were treated intraperitoneally with saline, or 0.25 or 2.5 mg of deprenyl/kg b.w. daily for 4 weeks prior to the administration of DMBA. Following the administration of DMBA, the rats were treated with saline or deprenyl daily for 27 weeks. At the end of the treatment period, there was a significant reduction in the tumor incidence and tumor number in rats that received 2.5 mg/kg deprenyl before and after the administration of DMBA and also in rats that were treated with 2.5 mg/kg deprenyl following DMBA. There also was a significant decrease in tumor number in rats that were treated with 0.25 mg/kg deprenyl during the entire treatment period of 31 weeks. Body weight increased throughout the treatment period with no significant differences between the groups. Treatment of rats with 2.5 mg of deprenyl following the administration of DMBA and also during the entire treatment period resulted in a significant decrease in the concentrations of the metabolites of norepinephrine (NE), dopamine (DA) and serotonin (5-HT) in the MBH, but there were no significant alterations in the concentrations of NE, DA and 5-HT in the MBH. These results suggest that the administration of deprenyl blocked the development of mammary tumors in part by inhibiting the metabolism of catecholamines and indoleamine and possibly by conferring a neuroprotective effect on the TIDA neurons in the MBH, especially at 0.25 mg/kg of deprenyl.
登录
查看更多内容
多巴胺激动剂对大鼠不同脑区自身受体功能的相对效力。
影响因子：
3.5
作者：
T. Westfall;L. Naes;C. Paul
通讯作者：
C. Paul
Deprenyl（司来吉兰）：其发展历史和药理作用
DOI：
--
发表时间：
1983
期刊：
Acta Neurologica Scandinavica, Supplementum
影响因子：
--
作者：
Joseph Knoll
通讯作者：
Joseph Knoll
纹状体多巴胺、性活动和寿命。
DOI：
--
发表时间：
1989
期刊：
Life Science
影响因子：
--
作者：
J. Knoll;J. Dalló;T. T. Yen
通讯作者：
T. T. Yen
第20章神经-免疫相互作用
DOI：
--
发表时间：
1994
期刊：
影响因子：
--
作者：
S. Felten;D. Felten
通讯作者：
D. Felten
自然细胞介导的免疫。
影响因子：
--
作者：
R. Herberman;H. Holden
通讯作者：
H. Holden