Assessment of the genotoxicity of acrylamide.
Assessment of the genotoxicity of acrylamide.
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DOI：
10.2903/j.efsa.2022.7293
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发表时间：
2022-05
期刊：
影响因子：
--
通讯作者：
中科院分区：
文献类型：
--
作者：
EFSA被要求就最近发表的一篇文章发表声明，该文章重新审视了丙烯酰胺（AA）遗传毒性的证据。该说明由一个工作组编写，并在最后核准前得到CONTAM小组的核可。在解释职权范围时，声明考虑了AA致癌性的作用模式，包括遗传毒性和非遗传毒性效应。回顾了自2015年CONTAM专家组关于食品中AA的意见以来的相关出版物。几项新的研究报告了AA及其活性代谢物缩水甘油酰胺（GA）的致染色体断裂和致突变特性的积极结果。GA的DNA加合物在实验动物中由AA暴露诱导，并且也在人类中观察到。除了AA的遗传毒性外，还有证据表明通过产生活性氧进行的二次DNA氧化和可能导致AA致癌的非遗传毒性作用。这些研究扩展了CONTAM小组在其2015年意见中评估的信息，并支持其结论。该意见采用了EFSA指南中推荐的遗传毒性和致癌性物质的暴露范围（莫伊）方法，用于AA肿瘤效应的风险表征。根据评估的新数据，莫伊的方法仍然被认为是适当的，目前不需要更新2015年的意见。
EFSA was requested to deliver a statement on a recent publication revisiting the evidence for genotoxicity of acrylamide (AA). The statement was prepared by a Working Group and was endorsed by the CONTAM Panel before its final approval. In interpreting the Terms of Reference, the statement considered the modes of action underlying the carcinogenicity of AA including genotoxic and non‐genotoxic effects. Relevant publications since the 2015 CONTAM Panel Opinion on AA in food were reviewed. Several new studies reported positive results on the clastogenic and mutagenic properties of AA and its active metabolite glycidamide (GA). DNA adducts of GA were induced by AA exposure in experimental animals and have also been observed in humans. In addition to the genotoxicity of AA, there is evidence for both secondary DNA oxidation via generation of reactive oxygen species and for non‐genotoxic effects which may contribute to carcinogenesis by AA. These studies extend the information assessed by the CONTAM Panel in its 2015 Opinion, and support its conclusions. That Opinion applied the margin of exposure (MOE) approach, as recommended in the EFSA Guidance for substances that are both genotoxic and carcinogenic, for risk characterisation of the neoplastic effects of AA. Based on the new data evaluated, the MOE approach is still considered appropriate, and an update of the 2015 Opinion is not required at the present time.
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DOI：
10.1186/s41021-021-00175-5
发表时间：
2021-02-17
期刊：
Genes and environment : the official journal of the Japanese Environmental Mutagen Society
影响因子：
--
作者：
Hagio S;Tsuji N;Furukawa S;Takeuchi K;Hayashi S;Kuroda Y;Honma M;Masumura K
通讯作者：
Masumura K
影响因子：
2.7
作者：
Hansen, Siri Helland;Pawlowicz, Agnieszka J.;Brunborg, Gunnar
通讯作者：
Brunborg, Gunnar
影响因子：
--
作者：
Collí-Dulá RC;Friedman MA;Hansen B;Denslow ND
通讯作者：
Denslow ND
影响因子：
--
作者：
Ansar, Sabah;Siddiqi, Nikhat Jamal;Abudawood, Manal
通讯作者：
Abudawood, Manal
影响因子：
4.3
作者：
Chepelev, Nikolai L.;Gagne, Remi;Yauk, Carole L.
通讯作者：
Yauk, Carole L.