Review on molecular and therapeutic potential of thymoquinone in cancer.
Review on molecular and therapeutic potential of thymoquinone in cancer.
复制标题
百里醌在癌症中的分子和治疗潜力的综述。
DOI：
10.1080/01635581.2010.509832
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发表时间：
2010
期刊：
影响因子：
--
通讯作者：
Mohammad RM
中科院分区：
文献类型：
--
作者：
Banerjee S;Padhye S;Azmi A;Wang Z;Philip PA;Kucuk O;Sarkar FH;Mohammad RM
百里醌（TQ）是存在于黑籽油（Nigella sativa）中的主要生物活性成分，并已被测试其抗癌功效。在此，我们总结了TQ的分子作用机制及其在临床前模型中诱导细胞凋亡和抑制肿瘤生长的能力。TQ具有抗炎作用，它通过调节凋亡信号、抑制血管生成和细胞周期阻滞来抑制肿瘤细胞增殖。TQ的化学增敏大多局限于体外研究，在癌症的治疗策略中具有潜力。结果表明，基于癌细胞存活和进展的分子决定因素的细胞靶点，对肿瘤细胞耐药的治疗效果和治疗效果增强。已经有人尝试合成新的TQ类似物，这些类似物在杀死肿瘤细胞方面具有比母体TQ化合物更强的化学致敏潜力。根据已发表的报告，我们认为有必要进行进一步的深入研究，包括调查其生物利用度和人类受试者的I期毒性分析。这些研究的结果将有助于推动这一领域的发展，支持开展临床试验，以测试这种古老药物在癌症治疗中的效果。
Thymoquinone (TQ) is the predominant bioactive constituent present in black seed oil (Nigella sativa) and has been tested for its efficacy against cancer. Here, we summarize the literature about TQ’s molecular mechanism of action and its ability to induce apoptosis and inhibit tumor growth in preclinical models. TQ has anti-inflammatory effects, and it inhibits tumor cell proliferation through modulation of apoptosis signaling, inhibition of angiogenesis, and cell cycle arrest. Chemosensitization by TQ is mostly limited to in vitro studies, and it has potential in therapeutic strategy for cancer. The results favor efficacy and enhancement of therapeutic benefit against tumor cells resistant to therapy based on cellular targets that are molecular determinants for cancer cell survival and progression. There have been attempts to synthesize novel analogs of TQ directed toward superior effects in killing tumor cells with more enhanced chemosensitizing potential than parent TQ compound. Based on published reports, we believe that further in-depth studies are warranted including investigation of its bioavailability and Phase I toxicity profiling in human subjects. The results from such studies will be instrumental in advancing this field in support of initiating clinical trials for testing the effects of this ancient agent in cancer therapy.
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