unc-68 encodes a ryanodine receptor involved in regulating C. elegans body-wall muscle contraction.
unc-68 encodes a ryanodine receptor involved in regulating C. elegans body-wall muscle contraction.
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UNC-68编码参与调节秀丽隐杆线虫身体壁肌收缩的ryanodine受体。
DOI：
10.1083/jcb.134.4.885
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发表时间：
1996-08
影响因子：
7.8
通讯作者：
Anderson, P
中科院分区：
文献类型：
--
作者：
Maryon, EB;Coronado, R;Anderson, P
Striated muscle contraction is elicited by the release of stored calcium ions through ryanodine receptor channels in the sarcoplasmic reticulum. ryr-1 is a C. elegans ryanodine receptor homologue that is expressed in body-wall muscle cells used for locomotion. Using genetic methods, we show that ryr-1 is the previously identified locus unc-68. First, transposon-induced deletions within ryr-1 are alleles of unc-68. Second, transformation of unc-68 mutants with ryr-1 genomic DNA results in rescue of the Unc phenotype. unc-68 mutants move poorly, exhibiting an incomplete flaccid paralysis, yet have normal muscle ultrastructure. The mutants are insensitive to the paralytic effects of ryanodine, and lack detectable ryanodine-binding activity. The Unc-68 phenotype suggests that ryanodine receptors are not essential for excitation- contraction coupling in nematodes, but act to amplify a (calcium) signal that is sufficient for contraction.
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影响因子：
56.9
作者：
NELSON, MT;CHENG, H;LEDERER, WJ
通讯作者：
LEDERER, WJ
DOI：
10.1083/jcb.128.5.893
发表时间：
1995-03
期刊：
The Journal of cell biology
影响因子：
--
作者：
Giannini G;Conti A;Mammarella S;Scrobogna M;Sorrentino V
通讯作者：
Sorrentino V
影响因子：
3.5
作者：
LYNN, S;GILLESPIE, JI
通讯作者：
GILLESPIE, JI
影响因子：
2
作者：
CROLL, NA
通讯作者：
CROLL, NA
影响因子：
4.1
作者：
MARTY, I;VILLAZ, M;RONJAT, M
通讯作者：
RONJAT, M