Accuracy of echocardiographic indices for serial monitoring of right ventricular systolic function in patients with precapillary pulmonary hypertension.
Accuracy of echocardiographic indices for serial monitoring of right ventricular systolic function in patients with precapillary pulmonary hypertension.
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DOI：
10.1371/journal.pone.0187806
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发表时间：
2017
期刊：
影响因子：
3.7
通讯作者：
Nishimura M
中科院分区：
文献类型：
--
作者：
Sato T;Tsujino I;Ohira H;Oyama-Manabe N;Ito YM;Takashina C;Watanabe T;Nishimura M
右心室射血分数（RVEF）系列评估可预测肺动脉高压（PH）患者的临床结局。心脏磁共振成像（CMRI）可以监测RVEF，但其在临床实践中的适用性有限。本研究旨在检查毛细血管前PH患者中CMRI衍生的RVEF变化与超声心动图指标变化之间的相关性。在54例连续毛细血管前PH患者（肺动脉高压（PAH），n = 23;非PAH，n = 31）中，在基线和随访时评价了CMRI和RV收缩功能超声心动图指标。在随访期间，根据PH指南优化药物治疗。使用CMRI衍生的RVEF作为金标准，我们通过相关性分析和受试者工作特征（ROC）分析，并通过计算灵敏度，特异性和阳性和阴性预测值，检查了5个超声心动图指标的准确性。平均9.5个月后，CMRI衍生的RVEF从基线时的30.2% ± 10.6%改善至随访时的41.4% ± 11.3%。这些变化与5项超声心动图指标显著相关，即，%RV缩短分数（r = 0.27）、%RV面积变化（r = 0.46）、三尖瓣环平面收缩期偏移（TAPSE）（r = 0.84）、RV心肌性能指数（RVMPI）（r =-0.72）和收缩期外侧三尖瓣环运动速度（TVlat）（r = 0.66）。在这些指标中，%RV面积变化、TAPSE和TVlat与PAH和非PAH亚组中CMRI衍生的RVEF显著相关。ROC分析显示，超声心动图指标的改善预测CMRI衍生的RVEF的预定改善（>2.9%），TAPSE和TVlat显示出比其他三个指标更好的准确性。在毛细血管前PH患者中，超声心动图指数与CMRI衍生的RVEF变化适度相关。五个超声心动图指标之间的比较显示，TAPSE和TVlat比%RV缩短率、%RV面积变化和RVMPI提供更好的准确性。
Serial assessment of right ventricular ejection fraction (RVEF) predicts the clinical outcome of patients with pulmonary hypertension (PH). Cardiac magnetic resonance imaging (CMRI) enables RVEF monitoring, but its applicability is limited in clinical practice. This study aimed to examine the correlation between changes in CMRI-derived RVEF with those in echocardiographic indices in patients with precapillary PH. CMRI and echocardiographic indices of RV systolic function were evaluated at baseline and follow-up in 54 consecutive patients with precapillary PH (pulmonary arterial hypertension (PAH), n = 23; non-PAH, n = 31). During follow-up, medical treatment was optimized according to the guidelines for PH. Using CMRI-derived RVEF as the gold standard, we examined the accuracy of five echocardiographic indices by correlation analysis and receiver operating characteristic (ROC) analysis and by calculating sensitivity, specificity, and positive and negative predictive values. After an average period of 9.5 months, CMRI-derived RVEF improved from 30.2% ± 10.6% at baseline to 41.4% ± 11.3% at follow-up. These changes significantly correlated with those in the five echocardiographic indices, i.e., %RV fractional shortening (r = 0.27), %RV area change (r = 0.46), tricuspid annular plane systolic excursion (TAPSE) (r = 0.84), RV myocardial performance index (RVMPI) (r = −0.72), and systolic lateral tricuspid annular motion velocity (TVlat) (r = 0.66). Of these indices, %RV area change, TAPSE, and TVlat significantly correlated with those of CMRI-derived RVEF in both PAH and non-PAH subgroups. ROC analysis showed that improvement in echocardiographic indices predicted a pre-specified improvement in CMRI-derived RVEF (>2.9%), with TAPSE and TVlat showing better accuracy over the other three indices. Echocardiographic indices modestly correlate with the changes in CMRI-derived RVEF in precapillary PH patients. Comparison among the five echocardiographic indices revealed that TAPSE and TVlat provide better accuracy than %RV fractional shortening, %RV area change, and RVMPI.
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影响因子：
2.8
作者：
Hardegree, Evan L.;Sachdev, Arun;Kane, Garvan C.
通讯作者：
Kane, Garvan C.
影响因子：
37.8
作者：
Kawut SM;Lima JA;Barr RG;Chahal H;Jain A;Tandri H;Praestgaard A;Bagiella E;Kizer JR;Johnson WC;Kronmal RA;Bluemke DA
通讯作者：
Bluemke DA
影响因子：
9.7
作者：
Guazzi, Marco;Vicenzi, Marco;Guazzi, Maurizio D.
通讯作者：
Guazzi, Maurizio D.
影响因子：
2.8
作者：
Pirat, Bahar;McCulloch, Marti L.;Zoghbi, William A.
通讯作者：
Zoghbi, William A.
DOI：
10.1186/1532-429x-14-5
发表时间：
2012-01-12
期刊：
Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance
影响因子：
--
作者：
Mauritz GJ;Vonk-Noordegraaf A;Kind T;Surie S;Kloek JJ;Bresser P;Saouti N;Bosboom J;Westerhof N;Marcus JT
通讯作者：
Marcus JT