Radiosynthesis, Preclinical, and Clinical Positron Emission Tomography Studies of Carbon-11 Labeled Endogenous and Natural Exogenous Compounds.
Radiosynthesis, Preclinical, and Clinical Positron Emission Tomography Studies of Carbon-11 Labeled Endogenous and Natural Exogenous Compounds.
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DOI：
10.1021/acs.chemrev.2c00398
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发表时间：
2023-01-11
期刊：
影响因子：
62.1
通讯作者：
Bongarzone, Salvatore
中科院分区：
文献类型：
--
作者：
Shegani, Antonio;Kealey, Steven;Luzi, Federico;Basagni, Filippo;Machado, Joana do Mar;Ekici, Sevban Dogan;Ferocino, Alessandra;Gee, Antony D.;Bongarzone, Salvatore
世界上大多数主要医院都有正电子发射断层扫描（PET）中心，随着PET扫描仪灵敏度的提高和全身PET系统的引入，人们对使用短寿命放射性核素碳-11开发PET示踪剂的兴趣增加了。在过去的几十年里，方法的改进和全自动模块使得临床使用的碳-11示踪剂得以发展。用放射性核素取代一个碳-11主链对天然化合物进行放射性标记，提供了有关天然化合物生物化学的重要信息，并增加了对其在健康和患病状态下的体内行为的了解。人类生命所必需的内源性和天然化合物的数量是惊人的，从简单的醇到维生素和肽。本综述整理了迄今为止合成的所有碳-11放射性标记的内源性和天然外源性化合物，包括其放射化学方法和健康受试者的临床前和临床研究的基本信息。
The presence of positron emission tomography (PET) centers at most major hospitals worldwide, along with the improvement of PET scanner sensitivity and the introduction of total body PET systems, has increased the interest in the PET tracer development using the short-lived radionuclides carbon-11. In the last few decades, methodological improvements and fully automated modules have allowed the development of carbon-11 tracers for clinical use. Radiolabeling natural compounds with carbon-11 by substituting one of the backbone carbons with the radionuclide has provided important information on the biochemistry of the authentic compounds and increased the understanding of their in vivo behavior in healthy and diseased states. The number of endogenous and natural compounds essential for human life is staggering, ranging from simple alcohols to vitamins and peptides. This review collates all the carbon-11 radiolabeled endogenous and natural exogenous compounds synthesised to date, including essential information on their radiochemistry methodologies and preclinical and clinical studies in healthy subjects.
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影响因子：
2.7
作者：
Malkowski B;Wareluk P;Gorycki T;Skrobisz K;Studniarek M
通讯作者：
Studniarek M
影响因子：
5.6
作者：
Aranega-Bou P;de la O Leyva M;Finiti I;García-Agustín P;González-Bosch C
通讯作者：
González-Bosch C
影响因子：
--
作者：
Abed, Majed;Alzoubi, Kousi;Lang, Florian
通讯作者：
Lang, Florian
DOI：
10.3891/acta.chem.scand.41b-0511
发表时间：
1987-08-01
期刊：
ACTA CHEMICA SCANDINAVICA SERIES B-ORGANIC CHEMISTRY AND BIOCHEMISTRY
影响因子：
--
作者：
ANTONI, G;LANGSTROM, B
通讯作者：
LANGSTROM, B
DOI：
10.1002/jlcr.2580240203
发表时间：
1987-02-01
影响因子：
1.8
作者：
ANTONI, G;LANGSTROM, B
通讯作者：
LANGSTROM, B