Normal Uptake of (11)C-Acetate in Pancreas, Liver, Spleen, and Suprarenal Gland in PET.
Normal Uptake of (11)C-Acetate in Pancreas, Liver, Spleen, and Suprarenal Gland in PET.
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DOI：
10.1155/2017/5478068
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发表时间：
2017
影响因子：
2.7
通讯作者：
Studniarek M
中科院分区：
文献类型：
--
作者：
Malkowski B;Wareluk P;Gorycki T;Skrobisz K;Studniarek M
11 C-乙酸盐是放射性示踪剂，被认为是18F-氟脱氧葡萄糖的替代品。描述了11 C-乙酸盐在人体实质器官中的生物分布评价。 本研究纳入了60例连续患者，这些患者接受了11 C-醋酸盐PET CT检查，疑似肾癌或前列腺癌复发，结果为阴性（无复发肿瘤）。静脉注射720 MBq 11 C-醋酸盐后20 min，从颅底到大腿上部进行采集。通过测量胰腺（分别为钩突和体部）、肝脏、脾脏和左肾上腺中的摄取来评价分布。入选患者的临床数据显示这些器官无异常。 比较了~（11）C-乙酸根放射性示踪剂在不同器官中的生物分布。胰腺实质（SUV平均值6，4）中11 C-醋酸盐的标准化摄取值显著高于肝脏（SUV平均值3，3）、脾脏（SUV平均值4，5）或肾上腺（SUV平均值2，7）组织。胰头（SUV平均值6，4）和胰体（SUV平均值5，9）摄取之间无显著差异。在所有上述器官的情况下，两性之间或先前诊断的肿瘤（肾脏和前列腺）之间没有差异。 评价实质器官中的11 C-醋酸盐摄取差异将允许建立正常分布模式。胰腺高摄取可用于弥漫性非肿瘤性病理中器官功能的定量评估。
11C-Acetate is radiotracer being considered an alternative to 18F-fluorodeoxyglucose. Evaluation of 11C-acetate biodistribution in human parenchymal organs is described. 60 consecutive patients referred to 11C-acetate PET CT suspected of renal or prostate cancer relapse with negative results (no recurrent tumor) were included in the study. Acquisition from the base of skull to upper thigh was made 20 min after i.v. injection of 720 MBq of 11C-acetate. The distribution was evaluated by measuring the uptake in pancreas (uncinate process and body separately), liver, spleen, and left suprarenal gland. Clinical data of included patients showed no abnormalities in these organs. Biodistributions of 11C-acetate radiotracer were compared in different organs. Standardized uptake values of 11C-acetate were significantly higher in pancreatic parenchyma (SUV mean 6,4) than in liver (SUV mean 3,3), spleen (SUV mean 4,5), or suprarenal gland (SUV mean 2,7) tissues. No significant difference was found between pancreatic head (SUV mean 6,4) and body (SUV mean 5,9) uptake. In case of all aforementioned organs, there were no differences either between both sexes or between formerly diagnosed tumors (renal and prostate). Evaluation of 11C-acetate uptake differences in parenchymal organs will allow establishing normal patterns of distribution. High pancreatic uptake may be used in quantitative assessment of organ function in diffuse nonneoplastic pathology.
影响因子：
3.1
作者：
Lew D;Afghani E;Pandol S
通讯作者：
Pandol S
影响因子：
9.3
作者：
Hyun, Joo O.;Lodge, Martin A.;Wahl, Richard L.
通讯作者：
Wahl, Richard L.
DOI：
10.1016/s0006-291x(03)00265-1
发表时间：
2003-03-21
影响因子：
3.1
作者：
Swinnen, JV;Van Veldhoven, PP;Verhoeven, G
通讯作者：
Verhoeven, G