Expression of Cystatin SN significantly correlates with recurrence, metastasis, and survival duration in surgically resected non-small cell lung cancer patients.
Expression of Cystatin SN significantly correlates with recurrence, metastasis, and survival duration in surgically resected non-small cell lung cancer patients.
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Cystatin SN 的表达与手术切除的非小细胞肺癌患者的复发、转移和生存时间显着相关
DOI：
10.1038/srep08230
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发表时间：
2015-02-04
影响因子：
4.6
通讯作者：
Wen ZS
中科院分区：
文献类型：
--
作者：
Cao X;Li Y;Luo RZ;Zhang L;Zhang SL;Zeng J;Han YJ;Wen ZS
半胱氨酸蛋白酶抑制剂SN被认为与人类肿瘤有关，但其在非小细胞肺癌（NSCLC）中的临床意义尚未阐明。本研究的目的是评估Cystatin SN在手术切除的NSCLC患者中的表达的临床价值。采用免疫组织化学和荧光原位杂交技术对2002年4月至2005年3月174例手术切除的NSCLC患者的Cystatin SN蛋白表达和扩增情况进行分析。探讨CystatinSN表达与复发、转移及生存的关系。在复发和转移分析中，与低Cystatin SN表达的NSCLC相比，高表达的肿瘤更容易复发和转移（P 0.001）。与高Cystatin SN表达亚组相比，低Cystatin SN表达亚组的无病生存期（DFS）和总生存期（OS）显著延长（DFS，P 0.001; OS，P = 0.001）。多因素分析证实，Cystatin SN高表达与不良生存期相关（DFS，P = 0.001; OS，P = 0.006），是独立的预后指标。目前的研究表明，高表达的半胱氨酸蛋白酶抑制剂SN是一个重要的预后指标较高的复发率，转移风险和手术切除的NSCLC患者的生存率差。
Cystatin SN has been considered to be involved in human cancer, but its clinical significance in non-small cell lung cancer (NSCLC) has not been elucidated. The aim of this study was to evaluate the clinical value of Cystatin SN expression in patients with surgically resected NSCLCs. A retrospective analysis of 174 patients with surgically resected NSCLCs from April 2002 to March 2005 was performed with immunohistochemistry and fluorescence in situ hybridization to analyze the protein expression and amplification of Cystatin SN. The associations between Cystatin SN expression and recurrence, metastasis and survival were investigated. In recurrence and metastasis analysis, compared with low-Cystatin SN expression NSCLCs, high expression tumors were more likely to recur and metastasize (P 0.001). Disease-free survival (DFS) and overall survival (OS) were significantly prolonged in the low-Cystatin SN expression subgroup compared with the high-Cystatin SN expression subgroup (DFS, P 0.001; OS, P = 0.001). A multivariate analysis confirmed that high expression of Cystatin SN was associated with poor survival (DFS, P = 0.001; OS, P = 0.006) and was an independent prognostic indicator. The present study indicates that high expression of Cystatin SN is a significant prognostic indicator of a higher rate of recurrence, metastatic risk and poor survival in patients with surgically resected NSCLCs.
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影响因子：
4.6
作者：
Williams, BA;Sugimura, H;Yang, P
通讯作者：
Yang, P
影响因子：
5
作者：
Choi, Eun Hwa;Kim, Jong-Tae;Lee, Hee Gu
通讯作者：
Lee, Hee Gu
影响因子：
82.9
作者：
Kononen, J;Bubendorf, L;Kallioniemi, OP
通讯作者：
Kallioniemi, OP
DOI：
10.1097/jto.0b013e318206a221
发表时间：
2011-02
期刊：
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer
影响因子：
--
作者：
Travis WD;Brambilla E;Noguchi M;Nicholson AG;Geisinger KR;Yatabe Y;Beer DG;Powell CA;Riely GJ;Van Schil PE;Garg K;Austin JH;Asamura H;Rusch VW;Hirsch FR;Scagliotti G;Mitsudomi T;Huber RM;Ishikawa Y;Jett J;Sanchez-Cespedes M;Sculier JP;Takahashi T;Tsuboi M;Vansteenkiste J;Wistuba I;Yang PC;Aberle D;Brambilla C;Flieder D;Franklin W;Gazdar A;Gould M;Hasleton P;Henderson D;Johnson B;Johnson D;Kerr K;Kuriyama K;Lee JS;Miller VA;Petersen I;Roggli V;Rosell R;Saijo N;Thunnissen E;Tsao M;Yankelewitz D
通讯作者：
Yankelewitz D
影响因子：
254.7
作者：
Siegel, Rebecca;Naishadham, Deepa;Jemal, Ahmedin
通讯作者：
Jemal, Ahmedin