The Kaiser Permanente Northern California research program on genes, environment, and health (RPGEH) pregnancy cohort: study design, methodology and baseline characteristics.
The Kaiser Permanente Northern California research program on genes, environment, and health (RPGEH) pregnancy cohort: study design, methodology and baseline characteristics.
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DOI：
10.1186/s12884-016-1150-2
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发表时间：
2016-11-29
影响因子：
3.1
通讯作者：
Croen LA
中科院分区：
文献类型：
--
作者：
Hedderson MM;Ferrara A;Avalos LA;Van den Eeden SK;Gunderson EP;Li DK;Altschuler A;Woo S;Rowell S;Choudhary V;Xu F;Flanagan T;Schaefer C;Croen LA
产前暴露可能会对孕产妇和儿童的健康结果产生持久影响。为了更好地了解宫内环境对儿童短期和长期健康的影响，需要具有代表性的大型妊娠队列，提供关于广泛环境影响(包括生物和行为)的全面信息，并能够与产前、儿童和孕产妇健康结果相联系。北加州Kaiser Permanente(KPNC)的基因、环境和健康(RPGEH)妊娠队列研究计划是为了创建一个进行研究的资源，以更好地了解影响妇女和儿童健康的因素。在KPNC，招募被纳入常规的临床产前护理，这是一个综合的卫生保健提供系统。我们详细介绍了建立该队列的研究设计、数据收集和方法。我们还描述了KPNC潜在怀孕人群的基线特征和队列的代表性。虽然招募工作仍在进行中，但截至2014年10月，RPGEH怀孕队列包括16,977名孕妇(53%来自少数族裔)。RPGEH妊娠队列参与者同意在妊娠早期(平均胎龄9.1wks ± 4.2SD)和中期(平均胎龄18.1wks ± 5.5SD)采集血液样本，以备将来使用。女性被邀请完成一份关于健康史和生活方式的问卷。关于妇女在怀孕前、怀孕期间和怀孕后的临床和健康评估以及妇女和儿童健康结果的信息可在保健系统的电子健康记录中获得，这也使长期后续行动成为可能。这一具有产前生物检疫和临床数据的大型、种族和民族多样化的怀孕队列是未来研究宫内环境暴露以及母婴围产期和长期健康结果的宝贵资源。RPGEH妊娠队列的基线特征表明，它高度代表生活在北加州更广泛社区的潜在人口。本文的在线版本(doi：10.1186/s12884-0161150-2)包含补充材料，授权用户可以使用。
Exposures during the prenatal period may have lasting effects on maternal and child health outcomes. To better understand the effects of the in utero environment on children’s short- and long-term health, large representative pregnancy cohorts with comprehensive information on a broad range of environmental influences (including biological and behavioral) and the ability to link to prenatal, child and maternal health outcomes are needed. The Research Program on Genes, Environment and Health (RPGEH) pregnancy cohort at Kaiser Permanente Northern California (KPNC) was established to create a resource for conducting research to better understand factors influencing women’s and children’s health. Recruitment is integrated into routine clinical prenatal care at KPNC, an integrated health care delivery system. We detail the study design, data collection, and methodologies for establishing this cohort. We also describe the baseline characteristics and the cohort’s representativeness of the underlying pregnant population in KPNC. While recruitment is ongoing, as of October 2014, the RPGEH pregnancy cohort included 16,977 pregnancies (53 % from racial and ethnic minorities). RPGEH pregnancy cohort participants consented to have blood samples obtained in the first trimester (mean gestational age 9.1 weeks ± 4.2 SD) and second trimester (mean gestational age 18.1 weeks ± 5.5 SD) to be stored for future use. Women were invited to complete a questionnaire on health history and lifestyle. Information on women’s clinical and health assessments before, during and after pregnancy and women and children’s health outcomes are available in the health system’s electronic health records, which also allows long-term follow-up. This large, racially- and ethnically-diverse cohort of pregnancies with prenatal biospecimens and clinical data is a valuable resource for future studies on in utero environmental exposures and maternal and child perinatal and long term health outcomes. The baseline characteristics of RPGEH Pregnancy Cohort demonstrate that it is highly representative of the underlying population living in the broader community in Northern California. The online version of this article (doi:10.1186/s12884-016-1150-2) contains supplementary material, which is available to authorized users.
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