From Liver Fat to Cancer: Perils of the Western Diet.-猫眼课题宝

DOI：

10.3390/cancers13051095

发表时间：

2021-03-04

期刊：

Cancers

影响因子：

5.2

通讯作者：

中科院分区：

医学2区

文献类型：

作者：

Kim JY;He F;Karin M

来源链接：

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7961422/

非酒精性脂肪性肝炎（NASH）是一种常见的肝脏疾病，以脂肪肝、慢性组织损伤、炎症和纤维化为特征。NASH极大地增加了最常见的肝癌（肝细胞癌（HCC））的风险，肝细胞癌是全球癌症相关死亡的主要原因。在这里，我们讨论了西方饮食如何促进NASH和HCC的发展，特别强调胆固醇和不同代谢调节剂的作用。肝细胞癌（HCC）是最常见的原发性肝癌类型，是肥胖相关癌症的典型例子。肥胖症的流行导致非酒精性脂肪肝（NAFLD）的发病率大幅增加，这种疾病影响了三分之一的美国成年人。在约20%的这些个体中，单纯性肝脏脂肪变性（脂肪肝）进展为非酒精性脂肪性肝炎（NASH），其特征在于慢性肝损伤、炎症和纤维化。除了肝衰竭，NASH还大大增加了HCC的风险。在这里，我们讨论了控制从NAFLD到NASH和从NASH到HCC进展的代谢过程，特别强调了游离非酯化胆固醇在该过程中的作用。

Non-alcoholic steatohepatitis (NASH) is a common liver disease, characterized by fatty liver, chronic tissue damage, inflammation and fibrosis. NASH greatly increases the risk of the most common liver cancer, hepatocellular carcinoma (HCC), a leading cause of cancer related deaths worldwide. Here, we discuss how the Western Diet contributes to NASH and HCC development with a special emphasis on the roles of cholesterol and different metabolic regulators. Hepatocellular carcinoma (HCC), the most common type of primary liver cancer provides the prototypical example of an obesity-related cancer. The obesity epidemic gave rise to an enormous increase in the incidence of non-alcoholic fatty liver disease (NAFLD), a condition that affects one third of American adults. In about 20% of these individuals, simple liver steatosis (hepatosteatosis) progresses to non-alcoholic steatohepatitis (NASH) characterized by chronic liver injury, inflammation, and fibrosis. In addition to liver failure, NASH greatly increases the risk of HCC. Here we discuss the metabolic processes that control the progression from NAFLD to NASH and from NASH to HCC, with a special emphasis on the role of free-non-esterified cholesterol in the process.