Abdominal Intratesticular Islet-Xenograft Survival in Rats
Abdominal Intratesticular Islet-Xenograft Survival in Rats
复制标题
大鼠腹部睾丸异种移植物的存活
作者：
H. Selawry;K. Whittington;D. Bellgrau
We investigated the survival of islet xenografts in the abdominal testes of normal, diabetes-resistant ACI and Wistar-Lewis (W-L) and in diabetes-prone BB/Wor rats. Islets were isolated from hamster donors, and after a period in tissue culture, they were injected into the abdominal testes of diabetic rats. Postoperatively, the rats were divided into two treatment groups. Four ACI rats received antilymphocyte serum (ALS) injections over a period of 30 days, and 13 ACI, 15 W-L, and 13 BB/Wor rats were given cyclosporin (CsA) according to the following regimen: 25 mg/kg i.p. for 7 days, then 7 mg/kg i.p. for 23 days. On day 30, immunosuppression was stopped. The results showed that none of the ALS-treated ACI rats remained normoglycemic for >9 days. However, CsA therapy resulted in an extended mean duration of normoglycemia in the ACI and W-L rats of 160.0 ± 36.0 and 131.0 ± 31 days, respectively. By contrast, the mean duration of normoglycemia in the BB/Wor rats was 33.0 ± 4.0 days. Furthermore, all of the BB/Wor rats reverted to diabetes after CsA was stopped. Therefore, the concomitant administration of an antigenic islet xenograft with CsA led to a state of unresponsiveness only in diabetes-resistant but not in diabetes-prone rats. Because the BB/Wor rats have demonstrable T-lymphocyte dysfunction, they may be unable to generate the CsA-induced suppressor T-lymphocytes required for the long-term acceptance of the graft by the host.
环孢素诱导的耐受性需要能够启动免疫反应的抗原。
DOI：
--
发表时间：
1987
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Haug,CE;Gill,RG;Babcock,SK;Lafferty,KJ;Bellgrau,D;Weil3rd,R
通讯作者：
Weil3rd,R
环孢素 A 后大鼠胸腺的免疫病理学。
影响因子：
0.9
作者：
Beschorner,WE;Namnoum,JD;Hess,AD
通讯作者：
Hess,AD
保护抑制细胞：环孢菌素的关键作用。
影响因子：
6.2
作者：
Kupiec-Weglinski,JW;Filho,MA;Strom,TB;Tilney,NL
通讯作者：
Tilney,NL