Astrocyte elevated gene 1: biological functions and molecular mechanism in cancer and beyond.
Astrocyte elevated gene 1: biological functions and molecular mechanism in cancer and beyond.
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星形胶质细胞升高基因 1：癌症及其他疾病中的生物学功能和分子机制。
DOI：
10.1186/2045-3701-1-36
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发表时间：
2011-11-07
影响因子：
7.5
通讯作者：
Li M
中科院分区：
文献类型：
--
作者：
Ying Z;Li J;Li M
自发现以来，对星形胶质细胞升高基因 1 (AEG-1) 的研究近十年来，人们对该分子的了解不断扩大，从其在癌症生物学中的作用到生物功能背后的分子机制。作为一种多功能癌蛋白，AEG-1已被证明在多种类型的人类癌症中过度表达，并且肿瘤细胞中AEG-1的升高导致恶性侵袭性表型增强，包括强劲增殖、侵入周围组织、迁移、诱导新血管形成和增强化疗耐药性的能力增强。已发现 AEG-1 在肿瘤发生和进展中的多功能作用与多种信号级联相关，即 1) NF-kappa B 的激活，部分通过与 p65 直接相互作用； 2) AEG-1间接触发的PI3K/AKT信号传导； 3）通过间接激活MAPK和诱导LEF1来增强β-连环蛋白的转录活性； 4) 通过与SND1相互作用调节mi/siRNA介导的基因沉默； 5) 促进保护性自噬；除了可能未知的机制。几乎所有肿瘤类型中都可见 AEG-1 表达升高，并且在大多数情况下，AEG-1 与肿瘤进展和较差的患者生存率呈正相关。总而言之，AEG-1 可能代表潜在的预后生物标志物和治疗靶点。
Since its discovery, nearly one decade of research on astrocyte elevated gene 1 (AEG-1) has witnessed expanding knowledge of this molecule, ranging from its role in cancer biology to molecular mechanisms underlying the biological functions. As a multifunctional oncoprotein, AEG-1 has been shown to overexpress in multiple types of human cancer, and the elevation of AEG-1 in tumor cells leads to enhanced phenotypes characteristic of malignant aggressiveness, including increased abilities to proliferate robustly, to invade surrounding tissues, to migrate, to induce neovascularization, and to enhance chemoresistance. The multifunctional role of AEG-1 in tumor development and progression has been found to be associated with several signaling cascades, namely, 1) activation of NF-kappa B, partially through direct interaction with p65; 2) PI3K/AKT signaling triggered by AEG-1 indirectly; 3) enhancement of the transcriptional activity of beta-catenin by indirect activation of MAPK and induction of LEF1; 4) regulation of mi/siRNA-mediated gene silencing by interacting with SND1; and 5) promotion of protective autophagy; in addition to possibly unknown mechanisms. Elevated AEG-1 expression is seen in nearly all tumor types, and in most cases AEG-1 positively correlates with tumor progression and poorer patient survival. Taken together, AEG-1 might represent a potential prognostic biomarker and therapeutic target.
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影响因子：
50.3
作者：
Hu G;Chong RA;Yang Q;Wei Y;Blanco MA;Li F;Reiss M;Au JL;Haffty BG;Kang Y
通讯作者：
Kang Y
影响因子：
1.2
作者：
Jeon, Hyun Yong;Choi, Murim;Fisher, Paul B.
通讯作者：
Fisher, Paul B.
星形胶质细胞升高基因 1 通过抑制转录因子 FOXO1 促进乳腺癌增殖
影响因子：
8
作者：
Li, J.;Yang, L.;Li, M.
通讯作者：
Li, M.
DOI：
10.1073/pnas.0910936106
发表时间：
2009-12-15
影响因子：
11.1
作者：
Emdad, Luni;Lee, Seok-Geun;Fisher, Paul B.
通讯作者：
Fisher, Paul B.
AEG-1 的过度表达与人类非小细胞肺癌的肿瘤侵袭性和不良预后显着相关
影响因子：
7.3
作者：
Song, Libing;Li, Wen;Li, Jun
通讯作者：
Li, Jun