Cerebral autoregulation, beta amyloid, and white matter hyperintensities are interrelated.
Cerebral autoregulation, beta amyloid, and white matter hyperintensities are interrelated.
复制标题
脑自动调节，β-淀粉样蛋白和白质超强度相互关联。
DOI：
10.1016/j.neulet.2015.03.005
复制
发表时间：
2015-04-10
影响因子：
2.5
通讯作者：
Marshall RS
中科院分区：
文献类型：
--
作者：
Brickman AM;Guzman VA;Gonzalez-Castellon M;Razlighi Q;Gu Y;Narkhede A;Janicki S;Ichise M;Stern Y;Manly JJ;Schupf N;Marshall RS
新兴的研究将血管危险因素和脑血管健康与阿尔茨海默病（AD）的患病率和进展率联系起来。大脑在一定脑灌注压范围内维持恒定血流量的能力，或自动调节，可能促进和导致小血管脑血管疾病和AD相关淀粉样病变。在这里，我们研究了14名非痴呆老年人的脑自动调节、小血管脑血管疾病和淀粉样蛋白沉积之间的关系。脑自动调节功能降低与淀粉样蛋白沉积增加和白色高信号体积增加有关，而这两者又相互正相关。我们首次在人类中证明了AD病理学、小血管脑血管疾病和脑自动调节之间的相互关系。血管因素和AD病理不是独立的，而是相互作用的。
Emerging studies link vascular risk factors and cerebrovascular health to the prevalence and rates of progression in Alzheimer’s disease (AD). The brain’s ability to maintain constant blood flow across a range of cerebral perfusion pressures, or autoregulation, may both promote and result from small vessel cerebrovascular disease and AD-related amyloid pathology. Here, we examined the relationship among cerebral autoregulation, small vessel cerebrovascular disease, and amyloid deposition in 14 non-demented older adults. Reduced cerebral autoregulation, was associated with increased amyloid deposition and increased white matter hyperintensity volume, which, in turn were positively associated with each other. For the first time in humans, we demonstrate an interrelationship among AD pathology, small vessel cerebrovascular disease, and cerebral autoregulation. Vascular factors and AD pathology are not independent but rather appear to interact.
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DOI：
10.1016/j.jalz.2011.03.005
发表时间：
2011-05
期刊：
Alzheimer's & dementia : the journal of the Alzheimer's Association
影响因子：
--
作者：
McKhann GM;Knopman DS;Chertkow H;Hyman BT;Jack CR Jr;Kawas CH;Klunk WE;Koroshetz WJ;Manly JJ;Mayeux R;Mohs RC;Morris JC;Rossor MN;Scheltens P;Carrillo MC;Thies B;Weintraub S;Phelps CH
通讯作者：
Phelps CH
影响因子：
--
作者：
Brickman, Adam M.;Provenzano, Frank A.;Muraskin, Jordan;Manly, Jennifer J.;Blum, Sonja;Apa, Zoltan;Stern, Yaakov;Brown, Truman R.;Luchsinger, Jose A.;Mayeux, Richard
通讯作者：
Mayeux, Richard
影响因子：
11.3
作者：
Brickman AM;Sneed JR;Provenzano FA;Garcon E;Johnert L;Muraskin J;Yeung LK;Zimmerman ME;Roose SP
通讯作者：
Roose SP
影响因子：
2.9
作者：
Kuo, TBJ;Chern, CM;Hu, HH
通讯作者：
Hu, HH
影响因子：
--
作者：
Brickman, Adam M.;Honig, Lawrence S.;Scarmeas, Nikolaos;Tatarina, Oksana;Sanders, Linda;Albert, Marilyn S.;Brandt, Jason;Blacker, Deborah;Stern, Yaakov
通讯作者：
Stern, Yaakov