Harmonizing SUVs in multicentre trials when using different generation PET systems: prospective validation in non-small cell lung cancer patients.
Harmonizing SUVs in multicentre trials when using different generation PET systems: prospective validation in non-small cell lung cancer patients.
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DOI：
10.1007/s00259-013-2391-1
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发表时间：
2013-07
影响因子：
9.1
通讯作者：
Aide, Nicolas
中科院分区：
文献类型：
--
作者：
Lasnon, Charline;Desmonts, Cedric;Quak, Elske;Gervais, Radj;Do, Pascal;Dubos-Arvis, Catherine;Aide, Nicolas
我们前瞻性地评估了在非小细胞肺癌（NSCLC）患者中使用点扩散函数（PSF）重建进行诊断和定量分析的策略是否符合欧洲核医学协会（EANM）关于定量值统一的指南。为了获得符合EANM肿瘤正电子发射断层扫描（PET）成像（PSFEANM）指南的恢复系数（rc），使用NEMA NU-2模体来确定适用于psf重建图像的最佳滤波器。使用未过滤的PSF重建（PSFallpass）、PSFEANM和已知符合EANM指南的常规有序子集期望最大化（OSEM）算法重建52例连续NSCLC患者的PET数据。为了模拟患者在不同一代PET系统上接受治疗前和治疗后PET扫描的情况，将OSEM重建的标准化摄取值（suv）与PSFEANM和PSFallpass重建的suv进行比较。总的来说，在195个病变中，Bland-Altman分析显示PSFEANM和OSEM数据的平均比值分别为1.03[95%可信区间（CI） 0.94-1.12]和1.02（95%可信区间（CI） 0.90-1.14）。当分析病灶的大小和位置或患者的身体习惯和图像噪声时，没有发现差异。10例患者（84个病灶）接受了两次PET扫描以监测反应。使用欧洲癌症研究和治疗组织（EORTC）标准，OSEMPET1/OSEMPET2（现行标准）与OSEMPET1/PSFEANM-PET2或PSFEANM-PET1/OSEMPET2之间的kappa值几乎完全一致，分别为0.95 （95% CI 0.91-1.00）和0.99 （95% CI 0.96-1.00）。使用PSFallpass进行预处理或后处理（即OSEMPET1/PSFallpass- pet2或PSFallpass- pet1 /OSEMPET2）与kappa值分别为0.75 （95% CI 0.67-0.83）和0.86 （95% CI 0.78-0.94）的一致性明显降低。当使用不同世代的PET系统时，方案优化的图像和符合EANM指南允许可靠的治疗前和治疗后评估。在非小细胞肺癌患者中获得的这些数据可以外推到其他实体肿瘤。本文的在线版本（doi:10.1007/s00259-013-2391-1）包含补充材料，仅供授权用户使用。
We prospectively evaluated whether a strategy using point spread function (PSF) reconstruction for both diagnostic and quantitative analysis in non-small cell lung cancer (NSCLC) patients meets the European Association of Nuclear Medicine (EANM) guidelines for harmonization of quantitative values. The NEMA NU-2 phantom was used to determine the optimal filter to apply to PSF-reconstructed images in order to obtain recovery coefficients (RCs) fulfilling the EANM guidelines for tumour positron emission tomography (PET) imaging (PSFEANM). PET data of 52 consecutive NSCLC patients were reconstructed with unfiltered PSF reconstruction (PSFallpass), PSFEANM and with a conventional ordered subset expectation maximization (OSEM) algorithm known to meet EANM guidelines. To mimic a situation in which a patient would undergo pre- and post-therapy PET scans on different generation PET systems, standardized uptake values (SUVs) for OSEM reconstruction were compared to SUVs for PSFEANM and PSFallpass reconstruction. Overall, in 195 lesions, Bland-Altman analysis demonstrated that the mean ratio between PSFEANM and OSEM data was 1.03 [95 % confidence interval (CI) 0.94–1.12] and 1.02 (95 % CI 0.90–1.14) for SUVmax and SUVmean, respectively. No difference was noticed when analysing lesions based on their size and location or on patient body habitus and image noise. Ten patients (84 lesions) underwent two PET scans for response monitoring. Using the European Organization for Research and Treatment of Cancer (EORTC) criteria, there was an almost perfect agreement between OSEMPET1/OSEMPET2 (current standard) and OSEMPET1/PSFEANM-PET2 or PSFEANM-PET1/OSEMPET2 with kappa values of 0.95 (95 % CI 0.91–1.00) and 0.99 (95 % CI 0.96–1.00), respectively. The use of PSFallpass either for pre- or post-treatment (i.e. OSEMPET1/PSFallpass-PET2 or PSFallpass-PET1/OSEMPET2) showed considerably less agreement with kappa values of 0.75 (95 % CI 0.67–0.83) and 0.86 (95 % CI 0.78–0.94), respectively. Protocol-optimized images and compliance with EANM guidelines allowed for a reliable pre- and post-therapy evaluation when using different generation PET systems. These data obtained in NSCLC patients could be extrapolated to other solid tumours. The online version of this article (doi:10.1007/s00259-013-2391-1) contains supplementary material, which is available to authorized users.
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DOI：
10.1007/s00259-011-1934-6
发表时间：
2012-01-01
影响因子：
9.1
作者：
Liao, Shengri;Penney, Bill C.;Pu, Yonglin
通讯作者：
Pu, Yonglin
影响因子：
9.3
作者：
Benz, Matthias R.;Evilevitch, Vladimir;Weber, Wolfgang A.
通讯作者：
Weber, Wolfgang A.
DOI：
10.1007/s00259-009-1291-x
发表时间：
2010-04
影响因子：
9.1
作者：
Agarwal, Mohit;Brahmanday, Govinda;Bajaj, Sunil K.;Ravikrishnan, K. P.;Wong, Ching-Yee Oliver
通讯作者：
Wong, Ching-Yee Oliver
DOI：
10.2967/jnumed.109.063016
发表时间：
2009-08
期刊：
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
影响因子：
--
作者：
Kadrmas DJ;Casey ME;Conti M;Jakoby BW;Lois C;Townsend DW
通讯作者：
Townsend DW
影响因子：
9.3
作者：
Boellaard, Ronald
通讯作者：
Boellaard, Ronald