Proinflammatory activity and the sensitization of depressive-like behavior during maternal separation.
Proinflammatory activity and the sensitization of depressive-like behavior during maternal separation.
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DOI：
10.1037/a0023559
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发表时间：
2011-06
影响因子：
1.9
通讯作者：
Deak, Terrence
中科院分区：
文献类型：
--
作者：
Hennessy, Michael B.;Paik, Kristopher D.;Caraway, Jessica D.;Schiml, Patricia A.;Deak, Terrence
关键词：
当豚鼠幼仔在一个新的环境中被隔离几个小时时，它们表现出一种独特的被动行为反应，这种反应似乎是由促炎活动介导的。最近，我们观察到连续两天分离的幼崽在第二天表现出增强的（致敏的）被动反应。在实验1中，在第一次分离前接受50 ng抗炎细胞因子白细胞介素-10脑室内注射的幼鼠在第二天的分离中没有表现出敏感的行为反应。在实验2中，在第1天和第2天分离的幼犬，或仅在第2天分离的幼犬，在第5天分离时表现出被动反应的增加。在第1天分离前注射细菌抗原脂多糖（LPS， 75μg/kg体重，腹腔注射）的幼崽在数天后表现出被动行为的增加，而在第1天分离前注射生理盐水的幼崽则没有这种现象。然而，在第一天注射未分离的LPS，在第2天初始分离时没有增强反应。这些结果表明，免疫激活是必要的，但不足以解释隔离豚鼠幼鼠第二天被动行为的致敏，在最初分离期间增强促炎活性可能会在几天后促进致敏，并且致敏反应至少持续数天。
When guinea pig pups are isolated for a few hours in a novel environment, they exhibit a distinctive passive behavioral response that appears to be mediated by proinflammatory activity. Recently, we observed that pups separated on two consecutive days show an enhanced (sensitized) passive response on the second day. In Experiment 1, pups receiving intracerebroventricular infusion of 50 ng of the anti-inflammatory cytokine Interleukin-10 prior to a first separation failed to show a sensitized behavioral response to separation the next day. In Experiment 2, pups separated on Days 1 and 2, or just 2, showed an increase in passive responding during separation on Day 5. Pups injected with the bacterial antigen lipopolysacchride (LPS; 75μg/kg body weight, intraperitoneal) prior to separation on Day 1 showed an increase in passive behavior several days later not shown by pups injected with saline prior to Day 1 separation. However, injection of LPS without separation on the first day did not enhance responding during an initial separation on the second day. These results suggest that immune activation is necessary, but not sufficient, to account for the sensitization of passive behavior of isolated guinea pig pups the following day, that boosting proinflammatory activity during an initial separation may promote sensitization several days later, and that the sensitized response persists for at least several days.
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