Beyond iron: non-classical biological functions of bacterial siderophores.
Beyond iron: non-classical biological functions of bacterial siderophores.
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DOI：
10.1039/c4dt03559c
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发表时间：
2015-04-14
期刊：
影响因子：
--
通讯作者：
Nolan EM
中科院分区：
文献类型：
--
作者：
Johnstone TC;Nolan EM
细菌分泌称为铁载体的小分子，从周围环境中获取铁。60多年来，对这些分子的生物无机化学的研究，包括基础配位化学研究，为铁载体在细菌铁稳态中发挥的关键作用提供了深入了解。近年来，由于抗药性细菌的出现以及防止这些超级细菌在全球范围内崛起的必要性，了解细菌生命基础化学的重要性越来越突出。最近出现了越来越多的铁载体功能的能力以外的铁运输的报告，但“非经典”的铁载体功能的报告长期以来一直是铁运输。这些铁螯合剂的一个特殊的非经典功能，即抗生素活性，甚至在铁载体在铁转运中的作用建立之前就有记载。在这个角度来看，我们提出了一个过去和目前的工作到铁载体的非经典功能的阐述，并强调了我们预计这项研究的方向。例子包括铁载体作为锌载体、白垩载体和各种其他金属的金属载体的能力，螯合重金属毒素，运输硼，作为信号分子，调节氧化应激，并提供抗菌活性。
Bacteria secrete small molecules known as siderophores to acquire iron from their surroundings. For over 60 years, investigations into the bioinorganic chemistry of these molecules, including fundamental coordination chemistry studies, have provided insight into the crucial role that siderophores play in bacterial iron homeostasis. The importance of understanding the fundamental chemistry underlying bacterial life has been highlighted evermore in recent years because of the emergence of antibiotic-resistant bacteria and the need to prevent the global rise of these superbugs. Increasing reports of siderophores functioning in capacities other than iron transport have appeared recently, but reports of “non-classical” siderophore functions have long paralleled those of iron transport. One particular non-classical function of these iron chelators, namely antibiotic activity, was even documented before the role of siderophores in iron transport was established. In this Perspective, we present an exposition of past and current work into non-classical functions of siderophores and highlight the directions in which we anticipate that this research is headed. Examples include the ability of siderophores to function as zincophores, chalkophores, and metallophores for a variety of other metals, sequester heavy metal toxins, transport boron, act as signalling molecules, regulate oxidative stress, and provide antibacterial activity.
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影响因子：
2.1
作者：
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通讯作者：
ARCHIBALD, F
影响因子：
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影响因子：
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作者：
Abergel, Rebecca J.;Clifton, Matthew C.;Pizarro, Juan C.;Warner, Jeffrey A.;Shuh, David K.;Strong, Roland K.;Raymond, Kenneth N.
通讯作者：
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影响因子：
5
作者：
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通讯作者：
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影响因子：
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作者：
Adler C;Corbalan NS;Peralta DR;Pomares MF;de Cristóbal RE;Vincent PA
通讯作者：
Vincent PA