Prognostic role of miR-17-92 family in human cancers: evaluation of multiple prognostic outcomes.
Prognostic role of miR-17-92 family in human cancers: evaluation of multiple prognostic outcomes.
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miR-17-92 家族在人类癌症中的预后作用：多种预后结果的评估
DOI：
10.18632/oncotarget.19096
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发表时间：
2017-09-15
期刊：
影响因子：
--
通讯作者：
Xiang H
中科院分区：
文献类型：
--
作者：
Liu F;Zhang F;Li X;Liu Q;Liu W;Song P;Qiu Z;Dong Y;Xiang H
最近的证据表明，miR-17-92家族可能是人类癌症的重要预后生物标志物。然而，结果仍然不一致。因此，我们进行了荟萃分析，以评估miR-17-92家族在人类癌症预后中的预测作用。我们检索了PubMed、科克伦和Embase数据库中2017年3月31日之前发表的文献。我们的分析中包括26项研究。总体风险比（HR）显示，miR-17-92家族的高表达水平是总生存期（OS）差的预测因子：校正HR = 1.71，95%置信区间（CI）：1.39-2.11，p < 0.00001，无病生存期（DFS）差的预测因子：校正HR = 2.29，95% CI：1.41-3.72，p = 0.0008。然而，未发现miR-17-92家族表达与癌症无进展生存期（PFS）之间存在关联（p > 0.05）。亚组分析显示，miR-17-92家族的高表达与低OS相关（校正HR = 1.89，95% CI：1.43-2.49，p < 0.00001）和DFS在亚洲人中，（校正的HR = 2.83，95%CI：1.59-5.04，p = 0.0003），在高加索人中未发现相关性（p > 0.05）。miR-17-92家族在组织和血清样本中高表达对OS的HR分别为1.68（1.35-2.09）和2.20（1.08-4.46），对DFS的HR分别为1.73（0.80-3.74）和3.37（2.25-5.02）。研究还发现，miR-17-92家族的高表达预示着乳腺癌、食管鳞状细胞癌、淋巴瘤等癌症的OS较差。研究结果表明，miR-17-92家族可以作为癌症患者预后预测的有效预测因子。
Recent evidence indicates that miR-17–92 family might be an essential prognostic biomarker for human cancers. However, results are still inconsistent. We therefore performed a meta-analysis to evaluate the predictive role of miR-17–92 family in human cancer prognosis. We searched literatures published before March 31th, 2017 inPubMed, Cochrane and Embase databases. Twenty six studies were included in our analyses. The overall hazard ratios (HRs) showed that high expression level of miR-17-92 family was a predictor of poor overall survival (OS): adjusted HRs = 1.71, 95% confidence intervals (CIs): 1.39–2.11, p < 0.00001, and poor disease-free survival (DFS): adjusted HRs = 2.29, 95% CIs: 1.41–3.72, p = 0.0008. However, no association between miR-17-92 family expression and cancer progress-free survival (PFS) was found (p > 0.05). Subgroup analyses showed that high expression of miR-17-92 family was associated with poor OS (adjusted HRs = 1.89, 95% CIs: 1.43–2.49, p < 0.00001) and DFS (adjusted HRs = 2.83, 95% CIs: 1.59–5.04, p = 0.0003) among the Asian, and no association was found for the Caucasian (p > 0.05). Besides, the HRs of miR-17-92 family high expression in tissue and serum samples was 1.68 (1.35–2.09) and 2.20 (1.08–4.46) for OS, and 1.73 (0.80–3.74) and 3.37 (2.25–5.02) for DFS. It also found that high expression of miR-17-92 family predicted a poor OS in breast cancer, esophageal squamous cell carcinoma, lymphoma and other cancers. Findings suggest that miR-17-92 family can be an effective predictor for prognosis prediction in cancer patients.
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