A Tumbling Magnetic Microrobot System for Biomedical Applications.
A Tumbling Magnetic Microrobot System for Biomedical Applications.
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DOI：
10.3390/mi11090861
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发表时间：
2020-09-17
期刊：
影响因子：
3.4
通讯作者：
Cappelleri DJ
中科院分区：
文献类型：
--
作者：
Niedert EE;Bi C;Adam G;Lambert E;Solorio L;Goergen CJ;Cappelleri DJ
一种微型机器人系统已经被开发出来，该系统包括一个无拴系的滚动式磁性微型机器人，一个两自由度旋转的永磁体，以及一个用于体外和体内生物医学应用的超声成像系统。由于旋转磁铁施加的磁力矩，微型机器人在净向前运动中端对端翻滚。通过旋转磁铁的旋转轴，可以实现二维方向控制，微机器人可以沿着包括圆形路径和P形路径在内的各种轨迹进行操纵。微型机器人能够在体外、原位和体内条件下在小鼠结肠内的非结构化地形上移动，以及在体外条件下在猪结肠上移动。高频超声成像可以在微型机器人被动物组织光学遮挡时实时确定其位置。当涂有荧光素有效载荷时，微型机器人被证明在1小时内在磷酸盐缓冲盐水中释放了大部分有效载荷。细胞毒性试验表明，微型机器人的组成材料SU-8和聚二甲基硅氧烷(PDMS)对小鼠成纤维细胞的毒性与阴性对照没有显著差异，即使在材料中掺入磁性钕微粒也是如此。微型机器人系统的能力使其在靶向药物输送和其他体内生物医学应用方面前景看好。
A microrobot system comprising an untethered tumbling magnetic microrobot, a two-degree-of-freedom rotating permanent magnet, and an ultrasound imaging system has been developed for in vitro and in vivo biomedical applications. The microrobot tumbles end-over-end in a net forward motion due to applied magnetic torque from the rotating magnet. By turning the rotational axis of the magnet, two-dimensional directional control is possible and the microrobot was steered along various trajectories, including a circular path and P-shaped path. The microrobot is capable of moving over the unstructured terrain within a murine colon in in vitro, in situ, and in vivo conditions, as well as a porcine colon in ex vivo conditions. High-frequency ultrasound imaging allows for real-time determination of the microrobot’s position while it is optically occluded by animal tissue. When coated with a fluorescein payload, the microrobot was shown to release the majority of the payload over a 1-h time period in phosphate-buffered saline. Cytotoxicity tests demonstrated that the microrobot’s constituent materials, SU-8 and polydimethylsiloxane (PDMS), did not show a statistically significant difference in toxicity to murine fibroblasts from the negative control, even when the materials were doped with magnetic neodymium microparticles. The microrobot system’s capabilities make it promising for targeted drug delivery and other in vivo biomedical applications.
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影响因子：
4.6
作者：
Alford, Aaron;Rich, Megan;Kharlampieva, Eugenia
通讯作者：
Kharlampieva, Eugenia
细胞膜——用于生物医学应用的伪装胶体马达
影响因子：
4.6
作者：
Gao, Changyong;Lin, Zhihua;He, Qiang
通讯作者：
He, Qiang
影响因子：
25
作者：
Barbot，Antoine;Tan，Haijie;Yang，Guang-Zhong
通讯作者：
Yang，Guang-Zhong
DOI：
10.1097/meg.0b013e328361dcd3
发表时间：
2013-08-01
影响因子：
2.1
作者：
Denters, Maaike J.;Schreuder, Marthe;Dekker, Evelien
通讯作者：
Dekker, Evelien
影响因子：
29.4
作者：
Gultepe, Evin;Randhawa, Jatinder S.;Kadam, Sachin;Yamanaka, Sumitaka;Selaru, Florin M.;Shin, Eun J.;Kalloo, Anthony N.;Gracias, David H.
通讯作者：
Gracias, David H.