Mechanoreceptor signal convergence and transformation in the dorsal horn flexibly shape a diversity of outputs to the brain.
Mechanoreceptor signal convergence and transformation in the dorsal horn flexibly shape a diversity of outputs to the brain.
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DOI：
10.1016/j.cell.2022.10.012
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发表时间：
2022-11-23
期刊：
影响因子：
64.5
通讯作者：
Ginty, David D.
中科院分区：
文献类型：
--
作者：
Chirila, Anda M.;Rankin, Genelle;Tseng, Shih-Yi;Emanuel, Alan J.;Chavez-Martinez, Carmine L.;Zhang, Dawei;Harvey, Christopher D.;Ginty, David D.
脊髓背角（DH）的触觉编码及其对大脑触觉表征的影响尚不清楚。通过一系列施加于皮肤的机械刺激、大规模体内电生理记录和基因操作，我们发现小鼠脊髓DH中的神经元接受来自低阈值和高阈值机械受体亚型的趋同输入，并表现出六种功能不同的机械反应谱之一。由具有不同机械反应特征的中间神经元组成的DH前馈或反馈抑制基序的遗传破坏揭示了一个广泛互联的DH网络，该网络能够动态、灵活地调节突触后背柱（PSDC）输出神经元，并决定初级体感皮层中的神经元如何对触摸做出反应。因此，机械感受器亚型收敛和非线性转换在体感层次的早期阶段决定了皮肤的触摸在大脑中的表现。在体感觉通路的早期阶段，脊髓背角神经元在接收和整合来自无害触摸刺激的趋同输入时表现出功能多样性；背角的相互连接网络和局部动态形成了体感觉皮层神经元多样性和触觉表征。
The encoding of touch in the spinal cord dorsal horn (DH) and its influence on tactile representations in the brain are poorly understood. Using a range of mechanical stimuli applied to the skin, large scale in vivo electrophysiological recordings, and genetic manipulations, here we show that neurons in the mouse spinal cord DH receive convergent inputs from both low- and high-threshold mechanoreceptor subtypes and exhibit one of six functionally distinct mechanical response profiles. Genetic disruption of DH feedforward or feedback inhibitory motifs, comprised of interneurons with distinct mechanical response profiles, revealed an extensively interconnected DH network that enables dynamic, flexible tuning of postsynaptic dorsal column (PSDC) output neurons and dictates how neurons in primary somatosensory cortex respond to touch. Thus, mechanoreceptor subtype convergence and nonlinear transformations at the earliest stage of the somatosensory hierarchy shape how touch of the skin is represented in the brain. At the earliest stage of the somatosensory pathway, the spinal cord dorsal horn neurons exhibit functionally diversity where they receive and integrate convergent inputs from non-noxious touch stimuli; the interconnected network and local dynamics at dorsal horn shape output neuron diversity and tactile representations in the somatosensory cortex.
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