The porcine accessory carpal bone as a model for biologic joint replacement for trapeziometacarpal osteoarthritis.
The porcine accessory carpal bone as a model for biologic joint replacement for trapeziometacarpal osteoarthritis.
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DOI：
10.1016/j.actbio.2021.05.011
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发表时间：
2021-07-15
影响因子：
9.7
通讯作者：
Steinberg DR
中科院分区：
文献类型：
--
作者：
Stoeckl BD;Zlotnick HM;Farrell MJ;Fryhofer GW;Hast MW;Miller LM;Sennett ML;Baxter JR;Schaer TP;Mauck RL;Steinberg DR
鉴于其复杂的形状和相对较小的尺寸，掌跖（TMC）关节处的胫骨表面是解剖生物关节表面置换的特别有吸引力的目标，特别是考虑到其发展骨关节炎的倾向以及有限和次优的治疗选择。然而，为了将其推进到临床转化，需要适当的大型动物模型。在这项研究中，我们探讨了猪副腕骨（ACB）作为人类腕关节模型。我们对ACB的解剖结构、几何结构、关节和组织尺度力学以及多个供体的组成进行了表征。我们发现，ACB是相似的大小，并在鞍形的主要关节面的人类椎骨，并在每个关节所经历的负载是相似的。利用这些信息，我们设计了一种制造方法和工作流程，以基于CT扫描生产患者特异性组织工程复制品，并表明当这种复制品在离体模型中原位植入时，正常负载恢复。本研究的数据建立了猪ACB作为模型系统，以评估工程活关节表面置换策略的功能。
Given its complex shape and relatively small size, the trapezium surface at the trapeziometacarpal (TMC) joint is a particularly attractive target for anatomic biologic joint resurfacing, especially given its propensity to develop osteoarthritis, and the limited and sub-optimal treatment options available. For this to advance to clinical translation, however, an appropriate large animal model is required. In this study, we explored the porcine accessory carpal bone (ACB) as a model for the human trapezium. We characterized ACB anatomy, geometry, joint and tissue-scale mechanics, and composition across multiple donors. We showed that the ACB is similar both in size, and in the saddle shape of the main articulating surface to the human trapezium, and that loads experienced across each joint are similar. Using this information, we then devised a fabrication method and workflow to produce patient-specific tissue-engineered replicas based on CT scans, and showed that when such replicas are implanted orthotopically in an ex vivo model, normal loading is restored. Data from this study establish the porcine ACB as a model system in which to evaluate function of engineered living joint resurfacing strategies.
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影响因子：
2.4
作者：
Hast, Michael W.;Hanson, Brett G.;Baxter, Josh R.
通讯作者：
Baxter, Josh R.
影响因子：
3.3
作者：
Sophia Fox AJ;Bedi A;Rodeo SA
通讯作者：
Rodeo SA
影响因子：
4.1
作者：
Ballyns, Jeffery J.;Gleghorn, Jason P.;Bonassar, Lawrence J.
通讯作者：
Bonassar, Lawrence J.
影响因子：
2.9
作者：
Gomoll, Andreas H.;Minas, Tom
通讯作者：
Minas, Tom
DOI：
10.1177/1558944717717506
发表时间：
2018-07-01
期刊：
Hand (New York, N.Y.)
影响因子：
--
作者：
Deutch, Zachary;Niedermeier, Steven R;Awan, Hisham M
通讯作者：
Awan, Hisham M