Evidence that primary visual cortex is required for image, orientation, and motion discrimination by rats.
Evidence that primary visual cortex is required for image, orientation, and motion discrimination by rats.
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DOI：
10.1371/journal.pone.0056543
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Reinagel P
中科院分区：
文献类型：
--
作者：
Petruno SK;Clark RE;Reinagel P
有色Long-Evans大鼠已被证明是一个很好的研究对象，包括定量视觉心理物理学的视觉引导行为。这一观察结果，连同其实验的可访问性和其密切的同源性的小鼠，使其成为一个有吸引力的模型系统，在其中解剖视知觉的丘脑和皮层电路。鉴于文献中已经描述了在初级视觉皮层不存在的情况下的视觉引导行为，然而，具体的视觉行为是否取决于大鼠的初级视觉皮层是一个经验问题。在这里，我们测试的影响，皮层病变的性能两个备选的强迫选择的视觉歧视Long-Evans大鼠。我们提供的数据来自一个高信息量的受试者，他学习了几项视觉任务，然后接受了双侧损伤消融>90%的初级视觉皮层。损伤后，与损伤前表现和假损伤对照组相比，该受试者在复杂图像辨别、方向辨别和全场光流运动辨别方面存在严重且持续的缺陷。然而，在另一项需要接近显着视觉目标的视觉二选一强制选择任务中，表现却完好无损。第二个高度信息化的受试者在接受>90%的内侧纹外皮质消融损伤之前学习了几项视觉任务。该受试者在四个任务类别中的任何一个上都没有表现出损伤。两者合计，我们的数据提供的证据表明，这些图像，方向和运动的歧视任务需要在Long-Evans大鼠的初级视觉皮层，而接近一个突出的视觉目标不。
The pigmented Long-Evans rat has proven to be an excellent subject for studying visually guided behavior including quantitative visual psychophysics. This observation, together with its experimental accessibility and its close homology to the mouse, has made it an attractive model system in which to dissect the thalamic and cortical circuits underlying visual perception. Given that visually guided behavior in the absence of primary visual cortex has been described in the literature, however, it is an empirical question whether specific visual behaviors will depend on primary visual cortex in the rat. Here we tested the effects of cortical lesions on performance of two-alternative forced-choice visual discriminations by Long-Evans rats. We present data from one highly informative subject that learned several visual tasks and then received a bilateral lesion ablating >90% of primary visual cortex. After the lesion, this subject had a profound and persistent deficit in complex image discrimination, orientation discrimination, and full-field optic flow motion discrimination, compared with both pre-lesion performance and sham-lesion controls. Performance was intact, however, on another visual two-alternative forced-choice task that required approaching a salient visual target. A second highly informative subject learned several visual tasks prior to receiving a lesion ablating >90% of medial extrastriate cortex. This subject showed no impairment on any of the four task categories. Taken together, our data provide evidence that these image, orientation, and motion discrimination tasks require primary visual cortex in the Long-Evans rat, whereas approaching a salient visual target does not.
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影响因子：
5.3
作者：
Andermann ML;Kerlin AM;Reid RC
通讯作者：
Reid RC
影响因子：
64.8
作者：
Bock, Davi D.;Lee, Wei-Chung Allen;Kerlin, Aaron M.;Andermann, Mark L.;Hood, Greg;Wetzel, Arthur W.;Yurgenson, Sergey;Soucy, Edward R.;Kim, Hyon Suk;Reid, R. Clay
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WEISKRANTZ, L
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作者：
DEAN, P
通讯作者：
DEAN, P
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作者：
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通讯作者：
ZEKI, S