Arbutin increases Caenorhabditis elegans longevity and stress resistance.
Arbutin increases Caenorhabditis elegans longevity and stress resistance.
复制标题
熊果苷可延长秀丽隐杆线虫的寿命和抗应激能力
作者：
Zhou L;Fu X;Jiang L;Wang L;Bai S;Jiao Y;Xing S;Li W;Ma J
熊果苷（对羟基苯基-β-D-吡喃葡萄糖苷）是一种著名的酪氨酸酶抑制剂，已被广泛用作化妆品增白剂。虽然它的天然作用是清除细胞内的自由基，但它也表现出用于治疗利尿、细菌感染和癌症的有用活性，以及抗炎和止咳活性。由于熊果苷清除自由基的功能也与抗氧化有关，而熊果苷对动物的长寿和抗应激能力的影响尚未得到证实，因此本文研究了熊果苷对秀丽隐杆线虫的影响。结果表明，最佳浓度的熊果苷可以延长寿命，增强抗氧化应激能力。这些作用的潜在分子机制涉及降低活性氧（ROS）水平，改善daf-16核定位，上调daf-16及其下游靶点（包括sod-3和hsp16.2）的表达。在这项工作中，熊果苷在寿命和健康中的作用进行了研究，结果支持熊果苷是一种保持整体健康的抗氧化剂。
Arbutin (p-hydroxyphenyl-β-D-glucopyranoside), a well-known tyrosinase inhibitor, has been widely used as a cosmetic whitening agent. Although its natural role is to scavenge free radicals within cells, it has also exhibited useful activities for the treatment of diuresis, bacterial infections and cancer, as well as anti-inflammatory and anti-tussive activities. Because function of free radical scavenging is also related to antioxidant and the effects of arbutin on longevity and stress resistance in animals have not yet been confirmed, here the effects of arbutin on Caenorhabditis elegans were investigated. The results demonstrated that optimal concentrations of arbutin could extend lifespan and enhance resistance to oxidative stress. The underlying molecular mechanism for these effects involves decreased levels of reactive oxygen species (ROS), improvement of daf-16 nuclear localization, and up-regulated expression of daf-16 and its downstream targets, including sod-3 and hsp16.2. In this work the roles of arbutin in lifespan and health are studied and the results support that arbutin is an antioxidant for maintaining overall health.
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DOI：
10.1186/2046-2395-3-6
发表时间：
2014
期刊：
Longevity & healthspan
影响因子：
--
作者：
Dai DF;Chiao YA;Marcinek DJ;Szeto HH;Rabinovitch PS
通讯作者：
Rabinovitch PS
影响因子：
4.5
作者：
Chiang WC;Tishkoff DX;Yang B;Wilson-Grady J;Yu X;Mazer T;Eckersdorff M;Gygi SP;Lombard DB;Hsu AL
通讯作者：
Hsu AL
影响因子：
2.7
作者：
Link, Pille;Wetterauer, Bernhard;Wink, Michael
通讯作者：
Wink, Michael
影响因子：
9.8
作者：
Li J;Ebata A;Dong Y;Rizki G;Iwata T;Lee SS
通讯作者：
Lee SS
影响因子：
56.9
作者：
Hsu, AL;Murphy, CT;Kenyon, C
通讯作者：
Kenyon, C