Fear-enhancing effects of septal oxytocin receptors.

Fear-enhancing effects of septal oxytocin receptors.
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DOI:
10.1038/nn.3465
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发表时间:
2013-09
影响因子:
25
通讯作者:
Radulovic, Jelena
Radulovic, Jelena
中科院分区:
医学1区
文献类型:
--
作者:
Guzman, Yomayra F.;Tronson, Natalie C.;Jovasevic, Vladimir;Sato, Keisuke;Guedea, Anita L.;Mizukami, Hiroaki;Nishimori, Katsuhiko;Radulovic, Jelena

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The nonapeptide oxytocin is considered beneficial to mental health due to its anxiolytic, prosocial and antistress effects, but evidence for anxiogenic actions of oxytocin in humans has recently emerged. Using region-specific manipulations of the mouse oxytocin receptor (Oxtr) gene (Oxtr), we identified the lateral septum as the brain region mediating fear-enhancing effects of Oxtr. These effects emerge after social defeat and require Oxtr specifically coupled to the extracellular signal–regulated protein kinase pathway.
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