Increased incidence of rare codon clusters at 5' and 3' gene termini: implications for function.
Increased incidence of rare codon clusters at 5' and 3' gene termini: implications for function.
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DOI:
10.1186/1471-2164-11-118
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发表时间:
2010-02-18
期刊:
影响因子:
4.4
通讯作者:
Clark PL
中科院分区:
文献类型:
--
作者:
Clarke TF 4th;Clark PL
The process of translation can be affected by the use of rare versus common codons within the mRNA transcript. Here, we show that rare codons are enriched at the 5' and 3' termini of genes from E. coli and other prokaryotes. Genes predicted to be secreted show significant enrichment in 5' rare codon clusters, but not 3' rare codon clusters. Surprisingly, no correlation between 5' mRNA structure and rare codon usage was observed. Potential functional roles for the enrichment of rare codons at terminal positions are explored.
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DOI:
10.1016/s0006-291x(02)00226-7
发表时间:
2002-04-26
影响因子:
3.1
作者:
Cortazzo, P;Cerve単ansky, C;Deana, A
通讯作者:
Deana, A
影响因子:
2.8
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通讯作者:
Katoh, Shigeo
影响因子:
4.5
作者:
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Huynen, Martijn A.
影响因子:
64.8
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通讯作者:
Brierley I
影响因子:
3.7
作者:
Clarke TF 4th;Clark PL
通讯作者:
Clark PL