Increased incidence of rare codon clusters at 5' and 3' gene termini: implications for function.

Increased incidence of rare codon clusters at 5' and 3' gene termini: implications for function.
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DOI:
10.1186/1471-2164-11-118
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发表时间:
2010-02-18
期刊:
影响因子:
4.4
通讯作者:
Clark PL
Clark PL
中科院分区:
生物学2区
文献类型:
--
作者:
Clarke TF 4th;Clark PL

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mRNA 转录本中稀有密码子与常见密码子的使用可能会影响翻译过程。在这里,我们发现稀有密码子在大肠杆菌和其他原核生物基因的 5' 和 3' 末端富集。预测分泌的基因在 5' 稀有密码子簇中显示出显着富集,但在 3' 稀有密码子簇中则没有。令人惊讶的是,没有观察到 5' mRNA 结构与稀有密码子使用之间的相关性。探索了末端位置稀有密码子富集的潜在功能作用。
The process of translation can be affected by the use of rare versus common codons within the mRNA transcript. Here, we show that rare codons are enriched at the 5' and 3' termini of genes from E. coli and other prokaryotes. Genes predicted to be secreted show significant enrichment in 5' rare codon clusters, but not 3' rare codon clusters. Surprisingly, no correlation between 5' mRNA structure and rare codon usage was observed. Potential functional roles for the enrichment of rare codons at terminal positions are explored.
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