Caloric restriction attenuates amyloid deposition in middle-aged dtg APP/PS1 mice.
Caloric restriction attenuates amyloid deposition in middle-aged dtg APP/PS1 mice.
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DOI：
10.1016/j.neulet.2009.08.038
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发表时间：
2009-10-30
影响因子：
2.5
通讯作者：
Ingram DK
中科院分区：
文献类型：
--
作者：
Mouton PR;Chachich ME;Quigley C;Spangler E;Ingram DK
热量限制（CR）减轻了由衰老和各种其他来源引起的神经损伤，包括表达与阿尔茨海默病（AD）相关的单和双转基因（tg）突变的年轻成年小鼠的神经病理学。为了评估CR预防相对严重的AD型病理学的潜力，共表达与家族性AD相关的两种突变，淀粉样前体蛋白（APP）和早老素1（PS1）的中年（13-14月龄）小鼠被喂食平衡饮食，其热量比随意喂食的对照组少40%。给药18周后，处死小鼠，并处理大脑，以定量海马结构和上覆新皮质中淀粉样蛋白β（Aβ）的总体积。计算机体视学证实，与年龄匹配的对照组相比，CR使总Aβ体积减少约三分之一。因此，CR似乎减弱了AD型神经病理学在中年dtg APP/ PS1小鼠的两个皮质脑区域中的积累。这些结果支持以下观点：CR可能是一种潜在有效的非药理学策略，可减少老年dtg APP/ PS1小鼠中相对较重的Aβ沉积，并可能对老年人AD的发作和进展提供类似的保护。
Caloric restriction (CR) mitigates neurological damage arising from aging and a variety of other sources, including neuropathology in young adult mice that express single and double transgenic (tg) mutations associated with Alzheimer disease (AD). To evaluate the potential of CR to protect against relatively heavy AD-type pathology, middle-aged (13-14 month-old) mice that co-express two mutations related to familial AD, amyloid precursor protein (APP) and presenilin 1 (PS1), were fed balanced diets with 40% fewer calories than ad libitum-fed controls. Following 18 weeks of treatment, mice were killed and brains processed for quantification of total volume of amyloid-beta (Aβ) in the hippocampal formation and the overlying neocortex. Computerized stereology confirmed that CR reduced the total Aβ volume by about one-third compared to that in age-matched controls. Thus, CR appears to attenuate the accumulation of AD-type neuropathology in two cortical brain regions of middle-aged dtg APP/ PS1 mice. These findings support the view that CR could be a potentially effective, non-pharmacology strategy for reducing relatively heavy Aβ deposition in older adult dtg APP/ PS1 mice, and possibly afford similar protection against the onset and progression of AD in older adult humans.
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影响因子：
3.5
作者：
GOODRICK, CL;INGRAM, DK;CIDER, NL
通讯作者：
CIDER, NL
DOI：
10.1196/annals.1297.074
发表时间：
2004-01-01
期刊：
STRATEGIES FOR ENGINEERED NEGLIGIBLE SENESCENCE: WHY GENUINE CONTROL OF AGING MAY BE FORESEEABLE
影响因子：
--
作者：
Ingram, DK;Anson, RM;Roth, GS
通讯作者：
Roth, GS
影响因子：
3.3
作者：
Jensen, MT;Mottin, MD;Arendash, GW
通讯作者：
Arendash, GW
影响因子：
82.9
作者：
Holcomb, L;Gordon, MN;Duff, K
通讯作者：
Duff, K
影响因子：
6
作者：
Callahan, MJ;Lipinski, WJ;Walker, LC
通讯作者：
Walker, LC