Investigating the biochemical impact of DNA damage with structure-based probes: abasic sites, photodimers, alkylation adducts, and oxidative lesions.
Investigating the biochemical impact of DNA damage with structure-based probes: abasic sites, photodimers, alkylation adducts, and oxidative lesions.
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DOI：
10.1021/bi901059k
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发表时间：
2009-10-13
期刊：
影响因子：
2.9
通讯作者：
Sturla SJ
中科院分区：
文献类型：
--
作者：
Dahlmann HA;Vaidyanathan VG;Sturla SJ
DNA sustains a wide variety of damage, such as the formation of abasic sites, pyrimidine dimers, alkylation adducts, or oxidative lesions, upon exposure to UV radiation, alkylating agents, or oxidative conditions. Since such damage may be acutely toxic or mutagenic and potentially carcinogenic, it is of interest to gain insight into how their structures impact biochemical processing of DNA, such as synthesis, transcription, and repair. Lesion-specific molecular probes have been used to study polymerase-mediated translesion DNA synthesis of abasic sites and TT dimers, while other probes have been developed to specifically investigate the alkylation adduct O6-Bn-G and the oxidative lesion 8-oxo-G. In this review recent examples of lesion-specific molecular probes are surveyed; their specificities of incorporation opposite target lesions compared to unmodified nucleotides are discussed, and limitations of their applications under physiologically relevant conditions are assessed.
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影响因子：
2.9
作者：
Berdis, AJ
通讯作者：
Berdis, AJ
DOI：
10.1016/0005-2787(73)90365-1
发表时间：
1973-01-01
期刊：
BIOCHIMICA ET BIOPHYSICA ACTA
影响因子：
--
作者：
CRADDOCK, VM
通讯作者：
CRADDOCK, VM
影响因子：
2.9
作者：
BOITEUX, S;LAVAL, J
通讯作者：
LAVAL, J
影响因子：
4.8
作者：
Carty, MP;Lawrence, CW;Dixon, K
通讯作者：
Dixon, K
研究肺炎球菌类型的诱导物质转化的化学性质：通过从III型肺炎球菌分离出的脱氧核糖核酸分数诱导转化。
DOI：
10.1084/jem.79.2.137
发表时间：
1944-02-01
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Avery OT;Macleod CM;McCarty M
通讯作者：
McCarty M