5-HT(1A) [corrected] receptors in mood and anxiety: recent insights into autoreceptor versus heteroreceptor function.
5-HT(1A) [corrected] receptors in mood and anxiety: recent insights into autoreceptor versus heteroreceptor function.
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DOI：
10.1007/s00213-013-3389-x
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发表时间：
2014-02
影响因子：
3.4
通讯作者：
Leonardo, E. David
中科院分区：
文献类型：
--
作者：
Garcia-Garcia, Alvaro L.;Newman-Tancredi, Adrian;Leonardo, E. David
5-羟色胺(5-HT)神经传递与焦虑和抑郁密切相关，许多证据支持主要抑制性5-羟色胺能受体-5-HT1A(5-HT1A)亚型参与了这两种疾病。在这篇综述中，我们考察了5-HT1a受体亚群的功能，并根据新的数据重新解释了它们在精神疾病中的作用，分离了内源性5-HT1a受体的空间作用(自体受体与异源受体)和时间作用(发育与成人)，强调了它们在调节焦虑和抑郁样行为方面的独特作用。用传统的遗传动物模型和药理学方法很难明确区分不同群体的5-HT1a受体的影响。然而，随着新的遗传系统和亚群选择性药物的出现，这些群体在控制情绪相关行为中的不同作用的直接证据正在涌现。越来越多的证据表明，在调节焦虑和抑郁样行为方面，自体和异型受体群体之间存在功能性分离。此外，虽然已经确定5-HT1A受体在发育过程中起到建立正常焦虑样行为的作用，但5-HT1A异种受体的发育作用尚不清楚，每个亚群发育作用的具体机制很可能是决定成年受试者情绪控制的关键因素。
Serotonin (5-HT) neurotransmission is intimately linked to anxiety and depression and a diverse body of evidence supports the involvement of the main inhibitory serotonergic receptor, the serotonin-1A (5-HT1A) subtype, in both disorders. In this review, we examine the function of 5-HT1A receptor sub-populations and re-interpret our understanding of their role in mental illness in light of new data, separating both spatial (autoreceptor vs heteroreceptor) and the temporal (developmental vs adult) roles of the endogenous 5-HT1A receptors, emphasizing their distinct actions in mediating anxiety and depression-like behaviors. It is difficult to unambiguously distinguish the effects of different populations of the 5-HT1A receptors with traditional genetic animal models and pharmacological approaches. However, with the advent of novel genetic systems and subpopulation-selective pharmacological agents, direct evidence for distinct roles of these populations in governing emotion related behavior are emerging. There is strong and growing evidence for a functional dissociation between auto and heteroreceptor populations in mediating anxiety and depressive-like behaviors respectively. Furthermore, while it is well established that 5-HT1A receptors act developmentally to establish normal anxiety-like behaviors, the developmental role of 5-HT1A heteroreceptors is less clear, and the specific mechanisms underlying the developmental role of each subpopulation are likely to be key elements determining mood control in adult subjects.
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DOI：
10.1111/j.1460-9568.2011.07936.x
发表时间：
2012-01
期刊：
The European journal of neuroscience
影响因子：
--
作者：
Bang SJ;Jensen P;Dymecki SM;Commons KG
通讯作者：
Commons KG
影响因子：
5.3
作者：
Celada, P;Puig, MV;Artigas, F
通讯作者：
Artigas, F
影响因子：
5
作者：
ANDREWS, N;HOGG, S;FILE, SE
通讯作者：
FILE, SE
影响因子：
4.7
作者：
Bortolozzi, A;Amargós-Bosch, M;Adell, A
通讯作者：
Adell, A
影响因子：
5
作者：
Bartoszyk, GD;Hegenbart, R;Ziegler, H
通讯作者：
Ziegler, H