Sleep and White Matter in Adults with Down Syndrome.
Sleep and White Matter in Adults with Down Syndrome.
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DOI：
10.3390/brainsci11101322
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发表时间：
2021-10-05
期刊：
影响因子：
3.3
通讯作者：
Hartley SL
中科院分区：
文献类型：
--
作者：
Fleming V;Piro-Gambetti B;Bazydlo A;Zammit M;Alexander AL;Christian BT;Handen B;Plante DT;Hartley SL
Adults with Down syndrome are at a high risk for disordered sleep. These sleep problems could have marked effects on aging and Alzheimer’s disease, potentially altering white matter integrity. This study examined the associations between disordered sleep assessed via an actigraph accelerometer worn on 7 consecutive nights, presence of diagnosis of obstructive sleep apnea, and diffusion tensor imaging indices of white matter integrity in 29 non-demented adults with Down Syndrome (48% female, aged 33–54 years). Average total sleep time was associated with lower mean diffusivity in the left superior longitudinal fasciculus (r = −0.398, p = 0.040). Average sleep efficiency, length of awakenings, and movement index were related to fractional anisotropy in the right inferior longitudinal fasciculus (r = −0.614 to 0.387, p ≤ 0.050). Diagnosis of obstructive sleep apnea was associated with fractional anisotropy in the right inferior longitudinal fasciculus (r = −0.373, p = 0.050). Findings suggest that more disrupted sleep is associated with lower white matter integrity in the major association tracts in middle-aged adults with Down syndrome. Longitudinal work is needed to confirm the directionally of associations. Sleep interventions could be an important component for promoting optimal brain aging in the Down syndrome population.
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影响因子：
3.5
作者：
Garyfallidis E;Brett M;Amirbekian B;Rokem A;van der Walt S;Descoteaux M;Nimmo-Smith I;Dipy Contributors
通讯作者：
Dipy Contributors
影响因子：
3.9
作者：
Carfì A;Antocicco M;Brandi V;Cipriani C;Fiore F;Mascia D;Settanni S;Vetrano DL;Bernabei R;Onder G
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Onder G
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4.3
作者：
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通讯作者：
Fortea, Juan
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3.3
作者：
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通讯作者：
Pierpaoli, C
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5.6
作者：
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通讯作者：
Shin, Chol