PLASMA GROWTH HORMONE PROFILES AND SLEEP: A STUDY OF 13 TREATED ACROMEGALICS
PLASMA GROWTH HORMONE PROFILES AND SLEEP: A STUDY OF 13 TREATED ACROMEGALICS
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血浆生长激素分布和睡眠：对 13 种经过处理的 ACROMEGALICS 的研究
DOI：
10.1111/j.1365-2265.1989.tb02233.x
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发表时间：
1989
影响因子：
3.2
通讯作者：
A. Seters
中科院分区：
文献类型：
--
作者：
H. Boer;F. Roelfsema;M. Frölich;H. Kamphuisen;A. Seters
对13例年龄29-67岁男性肢端肥大症患者的血浆生长激素水平和睡眠模式进行了研究。所有患者均在4-9年前接受了选择性垂体经蝶手术; 5例患者还接受了补充垂体照射。每隔20分钟采集一次血样;通过EEG获得睡眠模式。在胰岛素诱导的低血糖和GHRH（1-44）伴或不伴吡啶斯的明后评估GH储备。借助Pulsar程序对剖面图进行了分析。7/8例未接受放射治疗的患者出现1-3个夜间GH峰值;在接受放射治疗的患者中，仅1例患者的特征正常。胰岛素诱导的低血糖后，7/8例非辐照患者的GH储备正常，所有5例辐照患者的GH储备低于正常。在后一组中，当用GHRH测试时，GH储备减少。每组各有1例患者发生重度呼吸暂停综合征;在这两种情况下，夜间GH均未升高。与未接受放射治疗的患者相比，接受放射治疗的患者的睡眠阶段1的百分比较低，但其他14个睡眠参数没有差异。从这项研究中，我们得出结论，生长激素分泌的生理调节恢复手术治疗的患者。放射治疗可能导致垂体和下丘脑损伤，从而影响GH的自发分泌。
The plasma growth hormone profiles and sleep patterns of 13 treated male acromegalic patients, aged 29–67 years, were studied. All patients had undergone selective pituitary transsphenoidal surgery 4–9 years previously; five patients had also undergone supplemental pituitary irradiation. Blood samples were taken at 20‐min intervals; the sleep patterns were obtained by EEG. GH reserve was assessed after insulin‐induced hypoglycaemia and GHRH (1–44) with and without pyridostigmine. The profiles were analysed with the aid of the Pulsar program. Seven out of eight non‐irradiated patients had 1–3 nocturnal GH peaks; in the irradiated group only one patient had a normal profile. The GH reserve after insulin‐induced hypoglycaemia was normal in seven out of eight non‐irradiated patients, and subnormal in all five irradiated patients. In the latter group the GH reserve was diminished when tested with GHRH. One patient from each group had a severe apnoea syndrome; in both cases there was no nocturnal GH increase. The percentage sleep stage 1 was lower for irradiated patients when compared with non‐irradiated patients, but the 14 other sleep parameters did not differ. From this study we conclude that the physiological regulation of GH secretion is restored in surgically treated patients. Radiation therapy may lead to pituitary and hypothalamic damage, which could affect spontaneous GH secretion.
影响因子：
5.8
作者：
HO, KY;EVANS, WS;THORNER, MO
通讯作者：
THORNER, MO
年轻和老年男性睡眠期间的血浆生长激素。
DOI：
10.1093/geronj/38.5.519
发表时间：
1983
期刊：
Journal of gerontology
影响因子：
--
作者：
Prinz,PN;Weitzman,ED;Cunningham,GR;Karacan,I
通讯作者：
Karacan,I