Calcium-mediated mechanisms of cystic expansion.
Calcium-mediated mechanisms of cystic expansion.
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DOI：
10.1016/j.bbadis.2010.09.016
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发表时间：
2011-10
影响因子：
6.2
通讯作者：
Nauli, Surya M.
中科院分区：
文献类型：
--
作者：
Abdul-Majeed, Shakila;Nauli, Surya M.
In this review, we will discuss several well-accepted signaling pathways toward calcium-mediated mechanisms of cystic expansion. The second messenger calcium ion has contributed to a vast diversity of signal transduction pathways. We will dissect calcium signaling as a possible mechanism that contributes to renal cyst formation. Because cytosolic calcium also regulates an array of signaling pathways, we will first discuss cilia-induced calcium fluxes, followed by Wnt signaling that has attributed to much-discussed planar cell polarity. We will then look at the relationship between cytosolic calcium and cAMP as one of the most important aspects of cyst progression. The signaling of cAMP on MAPK and mTOR will also be discussed. We infer that while cilia-induced calcium fluxes may be the initial signaling messenger for various cellular pathways, no single signaling mediator or pathway is implicated exclusively in the progression of the cystic expansion.
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3.5
作者：
Hartman, Tiffiney R.;Liu, Dongyan;Zilfou, Jack T.;Robb, Victoria;Morrison, Tasha;Watnick, Terry;Henske, Elizabeth P.
通讯作者：
Henske, Elizabeth P.
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Caplan, MJ
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Olsen, Bjorn R.
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Guggino, WB