Asian lineage of peste des petits ruminants virus, Africa.

Asian lineage of peste des petits ruminants virus, Africa.
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DOI:
10.3201/eid1707.101216
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发表时间:
2011-07
影响因子:
11.8
通讯作者:
Libeau G
Libeau G
中科院分区:
医学2区
文献类型:
--
作者:
Kwiatek O;Ali YH;Saeed IK;Khalafalla AI;Mohamed OI;Obeida AA;Abdelrahman MB;Osman HM;Taha KM;Abbas Z;El Harrak M;Lhor Y;Diallo A;Lancelot R;Albina E;Libeau G

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小反刍兽疫病毒(PPRV)的宿主和地理分布的变化引起了人们的极大兴趣。在这项研究中,从2000 - 2009年期间苏丹临床疑似PPRV感染的骆驼、绵羊和山羊以及2008年摩洛哥首次报告爆发后不久的绵羊中收集生物标本。逆转录PCR分析证实了PPRV在整个苏丹的广泛分布和该病毒在摩洛哥的传播。对32个PPRV阳性样本的分子分型为亚洲谱系IV的引入和广泛传播提供了强有力的证据。该谱系进一步定义为2个亚群;一个亚群由骆驼和山羊分离株以及一些绵羊分离株组成,而另一个亚群仅包含绵羊分离株,这一发现表明根据宿主存在遗传偏倚。这项研究提供了PPRV谱系IV最近在非洲传播的证据。
Interest in peste des petits ruminants virus (PPRV) has been stimulated by recent changes in its host and geographic distribution. For this study, biological specimens were collected from camels, sheep, and goats clinically suspected of having PPRV infection in Sudan during 2000–2009 and from sheep soon after the first reported outbreaks in Morocco in 2008. Reverse transcription PCR analysis confirmed the wide distribution of PPRV throughout Sudan and spread of the virus in Morocco. Molecular typing of 32 samples positive for PPRV provided strong evidence of the introduction and broad spread of Asian lineage IV. This lineage was defined further by 2 subclusters; one consisted of camel and goat isolates and some of the sheep isolates, while the other contained only sheep isolates, a finding with suggests a genetic bias according to the host. This study provides evidence of the recent spread of PPRV lineage IV in Africa.
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