Lifetime risk for heart failure among white and black Americans: cardiovascular lifetime risk pooling project.
Lifetime risk for heart failure among white and black Americans: cardiovascular lifetime risk pooling project.
复制标题
DOI：
10.1016/j.jacc.2013.01.022
复制
发表时间：
2013-04-09
影响因子：
24
通讯作者：
Lloyd-Jones, Donald M.
中科院分区：
文献类型：
--
作者：
Huffman, Mark D.;Berry, Jarett D.;Ning, Hongyan;Dyer, Alan R.;Garside, Daniel B.;Cai, Xuan;Daviglus, Martha L.;Lloyd-Jones, Donald M.
按性别和种族估计心力衰竭的终生风险。此前估计，在以白人为主的人群中，终生发生心力衰竭 (HF) 的风险范围为 20% 至 33%。黑人的心衰短期风险似乎高于白人，但仅对心衰终生风险进行了有限的比较。我们利用 NHLBI 资助的队列的公开发布和内部数据集，估计了芝加哥心脏协会工业检测项目 (CHA)、社区动脉粥样硬化风险 (ARIC) 和心血管健康研究 (CHS) 队列参与者中 95 岁以下发生心力衰竭的终生风险，其中无心力衰竭死亡作为竞争事件。共有 39,578 名参与者（33,652 [85%] 白人；5,926 [15%] 黑人）进行了为期 716,976 人年的随访； 5,983 名参与者出现心力衰竭。 45 岁时，到 95 岁，CHA 和 CHS 的终生心衰风险在白人男性中为 30-42%，在黑人男性中为 20-29%，在白人女性中为 32-39%，在黑人女性中为 24-46%。 ARIC 的结果表明，75 岁之前的黑人和白人终生心力衰竭风险相似（随访限制）。无论是黑人还是白人，所有年龄段的血压和体重指数均较高，因此心衰的终生风险较高，并且不会随着指数年龄的增加而大幅降低。这些是比较黑人和白人终生心力衰竭风险的首批数据。心衰的终生风险很高，并且对于黑人和白人女性来说相似，但由于风险相互竞争，黑人的心衰风险略低于白人男性。
To estimate lifetime risk for HF by sex and race. Prior estimates of lifetime risk for developing heart failure (HF) range from 20% to 33% in predominantly white cohorts. Short-term risks for HF appear higher for blacks than whites, but only limited comparisons of lifetime risk for HF have been made. Using public-release and internal datasets from NHLBI-sponsored cohorts, we estimated lifetime risks for developing HF to age 95, with death free of HF as the competing event, among participants in Chicago Heart Association Detection Project in Industry (CHA), Atherosclerosis Risk in Communities (ARIC), and Cardiovascular Health Study (CHS) cohorts. There were 39,578 participants (33,652 [85%] white; 5,926 [15%] black) followed for 716,976 person-years; 5,983 participants developed HF. At age 45 years, lifetime risks for HF through age 95 years in CHA and CHS were 30-42% in white men, 20-29% in black men, 32-39% in white women, and 24-46% in black women. Results for ARIC demonstrated similar lifetime risks for HF in blacks and whites through age 75 years (limit of follow-up). Lifetime risk for HF was higher with higher BP and BMI at all ages in both blacks and whites and did not diminish substantially with advancing index age. These are among the first data to compare lifetime risks for HF between blacks and whites. Lifetime risks for HF are high and appear similar for black and white women, yet are somewhat lower for black compared with white men due to competing risks.
登录
查看更多内容
影响因子：
24
作者：
Avery, Christy L.;Loehr, Laura R.;Baggett, Christopher;Chang, Patricia P.;Kucharska-Newton, Anna M.;Matsushita, Kunihiro;Rosamond, Wayne D.;Heiss, Gerardo
通讯作者：
Heiss, Gerardo
影响因子：
37.8
作者：
Lloyd-Jones, DM;Larson, MG;Levy, D
通讯作者：
Levy, D
DOI：
10.1056/nejmoa1012848
发表时间：
2012-01-26
期刊：
The New England journal of medicine
影响因子：
--
作者：
Berry JD;Dyer A;Cai X;Garside DB;Ning H;Thomas A;Greenland P;Van Horn L;Tracy RP;Lloyd-Jones DM
通讯作者：
Lloyd-Jones DM
影响因子：
158.5
作者：
Levy, D;Kenchaiah, S;Vasan, RS
通讯作者：
Vasan, RS
影响因子：
37.8
作者：
Lloyd-Jones, DM;Leip, EP;Levy, D
通讯作者：
Levy, D