Impact of regurgitation on health-related quality of life in gastro-oesophageal reflux disease before and after short-term potent acid suppression therapy.
Impact of regurgitation on health-related quality of life in gastro-oesophageal reflux disease before and after short-term potent acid suppression therapy.
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DOI：
10.1136/gutjnl-2013-304883
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发表时间：
2014-05
期刊：
影响因子：
24.5
通讯作者：
Howden CW
中科院分区：
文献类型：
--
作者：
Kahrilas PJ;Jonsson A;Denison H;Wernersson B;Hughes N;Howden CW
关于胃食管反流病 (GORD) 反流对健康相关生活质量 (HRQOL) 影响的数据有限。我们评估了 GORD 抑酸治疗前后反流频率与 HRQOL 之间的关系。我们使用了 AZD0865 25-75 mg/天与埃索美拉唑 20 或 40 mg/天治疗非糜烂性反流病 (NERD) (n=1415) 或反流性食管炎 (RO) (n=1460) 的两项随机试验的数据。反流疾病问卷用于选择患有频繁且严重胃灼热的患者进行纳入并评估治疗反应。使用反流和消化不良的生活质量（QOLRAD）问卷来评估HRQOL。基线时，NERD 组和 RO 组中有 93% 的患者出现反流。 NERD 和 RO 在基线和第 4 周的平均 QOLRAD 评分相似，并且随着反流频率的增加，HRQOL 会下降；反流≥4天/周与<4天/周相比，平均QOLRAD评分存在>0.5的临床相关差异。在胃灼热反应者（轻度胃灼热每周≤1 天）中，第 4 周频繁、持续反流（≥4 天/周）的患病率在 NERD 中为 28%，在 RO 中为 23%。胃灼热反应者的 QOLRAD 分数较高。与整个组一样，胃灼热反应者与反流频率相关的影响模式相似。在 NERD 和 RO 中，频繁反流与临床相关的 HRQOL 逐渐下降相关，超出了强酸抑制前后胃灼热的相关性。临床试验编号NCT00206284和NCT00206245。
Limited data exist on the impact of regurgitation on health-related quality of life (HRQOL) in gastro-oesophageal reflux disease (GORD). We assessed the relationship between regurgitation frequency and HRQOL before and after acid suppression therapy in GORD. We used data from two randomised trials of AZD0865 25–75 mg/day vs. esomeprazole 20 or 40 mg/day in non-erosive reflux disease (NERD) (n=1415) or reflux oesophagitis (RO) (n=1460). The Reflux Disease Questionnaire was used to select patients with frequent and intense heartburn for inclusion and to assess treatment response. The Quality of Life in Reflux and Dyspepsia (QOLRAD) questionnaire was used to assess HRQOL. At baseline, 93% of patients in both the NERD and RO groups experienced regurgitation. Mean QOLRAD scores were similar for NERD and RO at baseline and at week 4 and disclosed decremental HRQOL with increasing frequency of regurgitation; a clinically relevant difference of >0.5 in mean QOLRAD scores was seen with regurgitation ≥4 days/week vs. <4 days/week. The prevalence of frequent, persistent regurgitation (≥4 days/week) at week 4 among heartburn responders (≤1 day/week of mild heartburn) was 28% in NERD and 23% in RO. QOLRAD scores were higher amongst heartburn responders. There was a similar pattern of impact related to regurgitation frequency in heartburn responders as in the group as a whole. Frequent regurgitation was associated with a clinically relevant, incremental decline in HRQOL beyond that associated with heartburn before and after potent acid suppression, in both NERD and RO. Clinical trial numbers NCT00206284 and NCT00206245.
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影响因子：
24.5
作者：
HOWDEN, CW;FORREST, JAH;REID, JL
通讯作者：
REID, JL
影响因子：
7.6
作者：
Sifrim, D.;Mittal, R.;Gregersen, H.
通讯作者：
Gregersen, H.
影响因子：
7.6
作者：
Jones, R.;Junghard, O.;Lind, T.
通讯作者：
Lind, T.
影响因子：
9.8
作者：
Talley, NJ;Fullerton, S;Wiklund, I
通讯作者：
Wiklund, I
影响因子：
9.8
作者：
Dent, John;Kahrilas, Peter J.;Lundborg, Per
通讯作者：
Lundborg, Per