Role of endoplasmic reticulum stress signalling in diabetic endothelial dysfunction and atherosclerosis.
Role of endoplasmic reticulum stress signalling in diabetic endothelial dysfunction and atherosclerosis.
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DOI：
10.1177/1479164116666762
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发表时间：
2017-01
影响因子：
2.4
通讯作者：
Chen H
中科院分区：
文献类型：
--
作者：
Dong Y;Fernandes C;Liu Y;Wu Y;Wu H;Brophy ML;Deng L;Song K;Wen A;Wong S;Yan D;Towner R;Chen H
众所周知，糖尿病加速动脉粥样硬化性血管疾病。内皮损伤被认为是动脉粥样硬化发病机制中的起始事件。内皮素不仅作为一种半选择性屏障，而且还具有生理和代谢功能。糖尿病或循环中的高葡萄糖引发一系列细胞内反应和器官损伤，如内皮功能障碍和细胞凋亡。一种这样的反应是高葡萄糖诱导的内皮细胞慢性内质网应激。未折叠蛋白质反应是一种急性反应，使细胞能够克服内质网应激。然而，当内质网应激反应长期持续时，最终可能导致内皮功能障碍和动脉粥样硬化。本文就内质网应激诱导的内皮功能障碍、糖尿病加速动脉粥样硬化的发病机制以及内质网应激作为糖尿病动脉粥样硬化治疗的潜在靶点等方面的研究进展进行综述。
It is well established that diabetes mellitus accelerates atherosclerotic vascular disease. Endothelial injury has been proposed to be the initial event in the pathogenesis of atherosclerosis. Endothelium not only acts as a semi-selective barrier but also serves physiological and metabolic functions. Diabetes or high glucose in circulation triggers a series of intracellular responses and organ damage such as endothelial dysfunction and apoptosis. One such response is high glucose-induced chronic endoplasmic reticulum stress in the endothelium. The unfolded protein response is an acute reaction that enables cells to overcome endoplasmic reticulum stress. However, when chronically persistent, endoplasmic reticulum stress response could ultimately lead to endothelial dysfunction and atherosclerosis. Herein, we discuss the scientific advances in understanding endoplasmic reticulum stress-induced endothelial dysfunction, the pathogenesis of diabetes-accelerated atherosclerosis and endoplasmic reticulum stress as a potential target in therapies for diabetic atherosclerosis.
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