Age-dependent expression changes of circadian system-related genes reveal a potentially conserved link to aging.
Age-dependent expression changes of circadian system-related genes reveal a potentially conserved link to aging.
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DOI：
10.18632/aging.203788
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发表时间：
2021-12-19
期刊：
影响因子：
--
通讯作者：
Marz M
中科院分区：
文献类型：
--
作者：
Barth E;Srivastava A;Wengerodt D;Stojiljkovic M;Axer H;Witte OW;Kretz A;Marz M
生物钟系统通过在生物体、组织和细胞中建立昼夜节律来影响生命的生物学，从而根据昼夜周期调节基本的生物过程。由于成熟和衰老，昼夜节律在一生中发生变化，昼夜节律系统控制的紊乱与多种与年龄相关的病理有关。然而，时间生物学和昼夜节律系统对健康器官和组织衰老的影响仍然很大程度上未知。昼夜节律系统调节的与衰老相关的变化是否在不同物种和组织中遵循保守模式，从而代表衰老的共同驱动力，目前尚不清楚。基于涵盖 329 个 RNA-Seq 文库的横断面转录组分析，我们发现昼夜节律系统受到进化上不同物种（例如智人、小家鼠、斑马鱼和 Nothobranchius Furzeri）之间共享的与衰老相关的基因改变的影响。我们通过比较成熟、老年和老年个体的组织特异性转录谱发现了差异表达的基因，并报告了昼夜节律系统的六个基因（per2、dec2、cirp、klf10、nfil3和dbp），这些基因在所检查的物种的四个器官中显示出保守的衰老相关表达模式。我们的结果说明了昼夜节律系统和衰老如何在漫长的生命周期中在各种组织中相互影响，并在概念上补充了先前追踪短期昼间和夜间基因表达振荡的研究。
The circadian clock system influences the biology of life by establishing circadian rhythms in organisms, tissues, and cells, thus regulating essential biological processes based on the day/night cycle. Circadian rhythms change over a lifetime due to maturation and aging, and disturbances in the control of the circadian system are associated with several age-related pathologies. However, the impact of chronobiology and the circadian system on healthy organ and tissue aging remains largely unknown. Whether aging-related changes of the circadian system’s regulation follow a conserved pattern across different species and tissues, hence representing a common driving force of aging, is unclear. Based on a cross-sectional transcriptome analysis covering 329 RNA-Seq libraries, we provide indications that the circadian system is subjected to aging-related gene alterations shared between evolutionarily distinct species, such as Homo sapiens, Mus musculus, Danio rerio, and Nothobranchius furzeri. We discovered differentially expressed genes by comparing tissue-specific transcriptional profiles of mature, aged, and old-age individuals and report on six genes (per2, dec2, cirp, klf10, nfil3, and dbp) of the circadian system, which show conserved aging-related expression patterns in four organs of the species examined. Our results illustrate how the circadian system and aging might influence each other in various tissues over a long lifespan and conceptually complement previous studies tracking short-term diurnal and nocturnal gene expression oscillations.
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影响因子：
5.1
作者：
Jawaid, Ali;Woldemichael, Bisrat T.;Mansuy, Isabelle M.
通讯作者：
Mansuy, Isabelle M.
影响因子：
7.8
作者：
Jonker MJ;Melis JP;Kuiper RV;van der Hoeven TV;Wackers PFK;Robinson J;van der Horst GT;Dollé ME;Vijg J;Breit TM;Hoeijmakers JH;van Steeg H
通讯作者：
van Steeg H
影响因子：
16.6
作者：
Aramillo Irizar P;Schäuble S;Esser D;Groth M;Frahm C;Priebe S;Baumgart M;Hartmann N;Marthandan S;Menzel U;Müller J;Schmidt S;Ast V;Caliebe A;König R;Krawczak M;Ristow M;Schuster S;Cellerino A;Diekmann S;Englert C;Hemmerich P;Sühnel J;Guthke R;Witte OW;Platzer M;Ruppin E;Kaleta C
通讯作者：
Kaleta C
影响因子：
5.2
作者：
Barth, Emanuel;Srivastava, Akash;Marz, Manja
通讯作者：
Marz, Manja
DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y