The CENP-A nucleosome: a battle between Dr Jekyll and Mr Hyde.
The CENP-A nucleosome: a battle between Dr Jekyll and Mr Hyde.
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DOI：
10.4161/nucl.23588
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发表时间：
2013-01
期刊：
影响因子：
--
通讯作者：
Dalal Y
中科院分区：
文献类型：
--
作者：
Bui M;Walkiewicz MP;Dimitriadis EK;Dalal Y
着丝粒特异性组蛋白着丝粒蛋白A（CENP-A）核小体的结构一直是过去五年争论的热点。提出的结构包括八聚体、六聚体、同型和异型四聚体。这一争论导致了CENP-A核小体在先前记录的体内和体外存在的多种状态之间经历细胞周期依赖性转变的提议。在我们实验室最近的工作中，我们试图验证这一假设。我们发现CENP-A核小体在人类细胞中经历独特的振荡，这一发现反映在芽殖酵母中进行的平行研究中。这篇评论提供了额外的见解CENP-A核小体物种的相互转化的潜在机制，并推测振荡在体内的生物学作用。
The structure of the centromere-specific histone centromeric protein A (CENP-A) nucleosome has been a hot topic of debate for the past five years. Structures proposed include octamers, hexamers, homotypic and heterotypic tetramers. This controversy has led to the proposal that CENP-A nucleosomes undergo cell-cycle dependent transitions between the multiple states previously documented to exist in vivo and in vitro. In recent work from our laboratory, we sought to test this hypothesis. We discovered that CENP-A nucleosomes undergo unique oscillations in human cells, a finding mirrored in a parallel study performed in budding yeast. This review provides additional insights into the potential mechanisms for the interconversion of CENP-A nucleosomal species, and speculates on a biological role for oscillations in vivo.
影响因子：
64.5
作者：
Westhorpe FG;Straight AF
通讯作者：
Straight AF