A sign-inverted receptive field of inhibitory interneurons provides a pathway for ON-OFF interactions in the retina.
A sign-inverted receptive field of inhibitory interneurons provides a pathway for ON-OFF interactions in the retina.
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DOI：
10.1038/s41467-023-41638-3
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发表时间：
2023-09-23
影响因子：
16.6
通讯作者：
Zhu, Yongling
中科院分区：
文献类型：
--
作者：
Jo, Andrew;Deniz, Sercan;Xu, Jian;Duvoisin, Robert M.;Devries, Steven H.;Zhu, Yongling
A fundamental organizing plan of the retina is that visual information is divided into ON and OFF streams that are processed in separate layers. This functional dichotomy originates in the ON and OFF bipolar cells, which then make excitatory glutamatergic synapses onto amacrine and ganglion cells in the inner plexiform layer. We have identified an amacrine cell (AC), the sign-inverting (SI) AC, that challenges this fundamental plan. The glycinergic, ON-stratifying SI-AC has OFF light responses. In opposition to the classical wiring diagrams, it receives inhibitory inputs from glutamatergic ON bipolar cells at mGluR8 synapses, and excitatory inputs from an OFF wide-field AC at electrical synapses. This “inhibitory ON center - excitatory OFF surround” receptive-field of the SI-AC allows it to use monostratified dendrites to conduct crossover inhibition and push-pull activation to enhance light detection by ACs and RGCs in the dark and feature discrimination in the light. In the retina, visual information is segregated into ON (light increment) and OFF (light decrement) streams. Here, the authors identify a sign-inverting amacrine cell with an inhibitory ON center – excitatory OFF surround receptive field.
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DOI：
10.1002/cne.22158
发表时间：
2009-11-10
期刊：
The Journal of comparative neurology
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