Extracellular Fluid Viscosity: Its Role in the Regulation of Membrane Lipid Metabolism and Cellular Secretion
Extracellular Fluid Viscosity: Its Role in the Regulation of Membrane Lipid Metabolism and Cellular Secretion
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细胞外液粘度：其在膜脂代谢和细胞分泌调节中的作用
DOI：
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发表时间：
1986
期刊：
影响因子：
--
通讯作者：
N. Reisfeld
中科院分区：
文献类型：
--
作者：
S. Yedgar;B. Sela;N. Reisfeld
血浆粘度由蛋白质和其他大分子的浓度决定，在与血浆蛋白过量产生相关的各种病理状态下升高（1）。血浆中白蛋白和其他大分子的浓度被认为参与了肝脏中蛋白质和脂质合成的控制（2）：对肾病动物的研究表明，由此产生的低白蛋白血症随后是白蛋白和脂蛋白合成速率的增加（3）。在肾病患者和实验动物中，输注大分子（如葡聚糖或白蛋白）可降低血浆脂蛋白水平（4）。这些观察结果似乎支持胶体渗透压（受大分子浓度控制）在决定肝血浆蛋白产生中起作用的假设，尽管其他研究给出了不确定的结果（5）。胶体渗透压假说在肝细胞培养物中得到进一步检验，肝细胞培养物是一个更明确和可控的系统（6，7）。增加培养基中各种大分子（葡聚糖、白蛋白和γ-球蛋白）的浓度对白蛋白的合成没有影响，但显著抑制极低密度脂蛋白（VLDL）的合成。然而，这种效果并没有相关的渗透压，质量浓度或化学性质的大分子存在于细胞外介质。
Plasma viscosity, which is determined by the concentration of proteins and other macromolecules, is elevated in various pathological states associated with the excess production of plasma proteins (1). The concentration of albumin and other macromolecules in the plasma have been assumed to be involved in the control of the synthesis of proteins and lipids in the liver (2): Studies with nephrotic animals have demonstrated that the resultant hypoalbuminemia is followed by increased rates of synthesis of albumins and lipoproteins (3). In both nephrotic patients and experimental animals, infusions of macromolecules, such as dextrans or albumin, reduced plasma lipoprotein levels (4). These observations seem to support the hypothesis that colloid osmotic pressure, which is governed by the macromolecule concentration, plays a role in determining hepatic plasma protein production, although other studies have given inconclusive results (5). The colloid osmotic pressure hypothesis was further examined in hepatocyte cultures, a more well defined and controllable system (6,7). Increasing the concentrations of various macromolecules (dextrans, albumins and γ-globulins) in the culture medium had no effect on albumin synthesis, but markedly inhibited the synthesis of very low density lipoproteins (VLDL). However this effect did not correlate with either osmolarity, mass concentration or the chemical nature of the macromolecules present in the extracellular medium.
溶剂成分和粘度对 CO 与血红素蛋白结合速率的影响。
DOI：
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发表时间：
1981
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
McKinnie,RE;Olson,JS
通讯作者：
Olson,JS
DOI：
10.1016/s0021-9258(18)34904-4
发表时间：
1982-03
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
S. Yedgar;D. B. Weinstein;W. Patsch;G. Schonfeld;F. E. Casanada;D. Steinberg
通讯作者：
S. Yedgar;D. B. Weinstein;W. Patsch;G. Schonfeld;F. E. Casanada;D. Steinberg
影响因子：
5.3
作者：
SEPLOWITZ, AH;CHIEN, S;SMITH, FR
通讯作者：
SMITH, FR