Differences in cAMP levels in tn- and non-tn-bearing mouse spermatozoa.

Differences in cAMP levels in tn- and non-tn-bearing mouse spermatozoa.
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携带 tn 和不携带 tn 的小鼠精子中 cAMP 水平的差异。

DOI:
10.1093/biolreprod/22.5.1102
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发表时间:
1980
影响因子:
3.6
通讯作者:
Hillman,N
Hillman,N
中科院分区:
生物学2区
文献类型:
--
作者:
Nadijcka,M;Hillman,N

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Cauda epididymal spermatozoa fromT/+, +/t6, BALB/c (+/+) and Swiss Webster albino (+/+) male mice, incubated for 1 h in sperm Ringer’s solution supplemented with 10 mM theophylline but no energy substrate, contained significantly different levels of cAMP. When 10 mM fructose was added to the medium, cAMP levels of some genotypes tested were elevated; however,T/t6spermatozoan populations did not demonstrate a change, whileT/+ samples contained significantly lower levels. In supplemented media containing 10 mM pyruvate, only +/t6andT/t6gamete populations had cAMP values that were significantly higher than those recorded following incubation in fructose. These enhanced cAMP concentrations are discussed in relation to the increased transmission frequency of thetnallele by the male.
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