Lactobacillus plantarum induces apoptosis in oral cancer KB cells through upregulation of PTEN and downregulation of MAPK signalling pathways.
Lactobacillus plantarum induces apoptosis in oral cancer KB cells through upregulation of PTEN and downregulation of MAPK signalling pathways.
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DOI：
10.15171/bi.2017.22
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发表时间：
2017
期刊：
影响因子：
--
通讯作者：
Omidi Y
中科院分区：
文献类型：
--
作者：
Asoudeh-Fard A;Barzegari A;Dehnad A;Bastani S;Golchin A;Omidi Y
前言：口腔肿瘤是世界上第六大最流行的癌症类型，也是癌症相关死亡的第二大原因。虽然化疗和免疫治疗是治疗口腔癌的主要策略，但对这些治疗方式出现不可避免的耐药性是导致口腔癌复发的主要缺点。如今，益生菌已被建议作为辅助和补充治疗方式，以改善化疗和免疫治疗药物的影响。益生菌是人体内友好的微生物区系，有助于产生有益的代谢物，对免疫系统产生积极作用，对抗各种疾病，如癌症。方法：植物乳杆菌是口腔中最重要的细菌之一，在人体口腔系统中普遍存在。本研究旨在探讨植物乳杆菌对口腔系统健康的影响，并通过实时定量聚合酶链式反应和流式细胞术分析，探讨植物乳杆菌抑制口腔癌KB细胞生长的分子机制。结果：植物乳杆菌通过上调和下调PTEN和MAPK信号转导通路，有效地促进了口腔癌细胞的信号转导。结论：植物乳杆菌对PTEN和MAPK途径功能表达的生物学效应表明，该菌在控制口腔系统不良肿瘤的发生中起着关键作用。综上所述，植物乳杆菌被认为是益生菌治疗癌症的潜在候选者。
Introduction: The oral tumor is the sixth most prevalent type of cancer worldwide and the second leading cause of cancer-related mortality. Although chemotherapy and immunotherapy are the main strategies for the treatment of oral cancer, an emergence of inevitable resistance to these treatment modalities is the major drawback that causes recurrence of the disease. Nowadays, probiotics have been suggested as adjunctive and complementary treatment modalities for improving the impacts of chemotherapy and immunotherapy agents. Probiotics, the friendly microflora in our bodies, contribute to the production of useful metabolites with positive effects on the immune system against various diseases such as cancer. Methods: Lactobacillus plantarum is one of the most important bacteria, which commensally live in the human oral system. In the current study, the impacts of L. plantarum on maintaining oral system health were investigated, and the molecular mechanisms of inhibition of oral cancer KB cells mediated by L. plantarum were evaluated using real-time polymerase chain reaction (PCR) and FACS flow cytometry analyses. Results: Our findings showed that L. plantarum is effective in the signal transduction of the oral cancer cells through upregulation and downregulation of PTEN and MAPK pathways, respectively. Conclusion: Based on the biological effects of oral candidate probiotics candidate bacterium L. plantarum on functional expression of PTEN and MAPK pathways, this microorganism seems to play a key role in controlling undesired cancer development in the oral system. Taken all, L. plantarum is proposed as a potential candidate for probiotics cancer therapy.
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DOI：
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发表时间：
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期刊：
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影响因子：
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