Poxvirus Bioinformatics Resource Center: a comprehensive Poxviridae informational and analytical resource.
Poxvirus Bioinformatics Resource Center: a comprehensive Poxviridae informational and analytical resource.
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DOI：
10.1093/nar/gki110
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发表时间：
2005-01-01
影响因子：
14.9
通讯作者：
Buller RM
中科院分区：
文献类型：
--
作者：
Lefkowitz EJ;Upton C;Changayil SS;Buck C;Traktman P;Buller RM
痘病毒生物信息学资源中心（PBRC）的建立是为了向科学界提供信息和分析资源，以帮助研究人员更好地了解痘病毒科病毒。由于担心天花的病原体天花病毒以及相关病毒可能被用作生物武器，专门设立了《预防天花病毒管制条例》。此外，中国卫生监督管理委员会支持对可能被认为是新的和正在出现的传染性病原体的痘病毒的研究，如猴痘病毒。PBRC由关系数据库和web应用程序组成，支持项目的数据存储、注释、分析和信息交换目标。目前的版本包括来自痘病毒科的各种属、种和毒株的超过35个完整的基因组序列。这些病毒的序列和注释信息已从GenBank公开提供的序列以及从正在进行的测序项目中获得的尚未存入GenBank的序列中获得。除了序列数据外，PBRC还提供病毒基因的全面注释和管理；帮助理解现有序列数据的分析工具，包括对不同病毒分离物进行比较分析的工具；和可视化工具，以帮助更好地显示各种分析的结果。PBRC代表了一个更全面的生物防御病毒生物信息学资源中心的初步发展，该中心将成为国家过敏和传染病研究所的“生物防御和新发或再发传染病生物信息学资源中心”之一。中国人民监督管理委员会网站：http://www.poxvirus.org。
The Poxvirus Bioinformatics Resource Center (PBRC) has been established to provide informational and analytical resources to the scientific community to aid research directed at providing a better understanding of the Poxviridae family of viruses. The PBRC was specifically established as the result of the concern that variola virus, the causative agent of smallpox, as well as related viruses, might be utilized as biological weapons. In addition, the PBRC supports research on poxviruses that might be considered new and emerging infectious agents such as monkeypox virus. The PBRC consists of a relational database and web application that supports the data storage, annotation, analysis and information exchange goals of the project. The current release consists of over 35 complete genomic sequences of various genera, species and strains of viruses from the Poxviridae family. Sequence and annotation information for these viruses has been obtained from sequences publicly available from GenBank as well as sequences not yet deposited in GenBank that have been obtained from ongoing sequencing projects. In addition to sequence data, the PBRC provides comprehensive annotation and curation of virus genes; analytical tools to aid in the understanding of the available sequence data, including tools for the comparative analysis of different virus isolates; and visualization tools to help better display the results of various analyses. The PBRC represents the initial development of what will become a more comprehensive Viral Bioinformatics Resource Center for Biodefense that will be one of the National Institute of Allergy and Infectious Diseases' ‘Bioinformatics Resource Centers for Biodefense and Emerging or Re-Emerging Infectious Diseases’. The PBRC website is available at http://www.poxvirus.org.
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影响因子：
14.9
作者：
Wheeler, DL;Church, DM;Wagner, L
通讯作者：
Wagner, L
影响因子：
14.9
作者：
Harris, MA;Clark, J;White, R
通讯作者：
White, R
影响因子：
3
作者：
Brodie, R;Smith, AJ;Upton, C
通讯作者：
Upton, C
影响因子：
5.8
作者：
Brodie, R;Roper, RL;Upton, C
通讯作者：
Upton, C
影响因子：
5
作者：
Upton, C;Hogg, D;Harris, NL
通讯作者：
Harris, NL