Epigenetic mechanisms regulate cue memory underlying discriminative behavior.
Epigenetic mechanisms regulate cue memory underlying discriminative behavior.
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DOI：
10.1016/j.neubiorev.2022.104811
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发表时间：
2022-10
影响因子：
8.2
通讯作者：
Bieszczad, Kasia M.
中科院分区：
文献类型：
--
作者：
Shang, Andrea;Bieszczad, Kasia M.
关键词：
新兴的神经表观遗传学领域引入了染色质修饰作为经验和大脑功能之间的重要接口。例如，组蛋白乙酰化和 DNA 甲基化等表观遗传机制在一生中发挥作用，有力地调节大脑中的基因表达，这是将经历转化为长期记忆所必需的。这篇综述强调了来自记忆感觉模型的新证据，这些模型的前提是感觉脑中活动依赖性转录的表观遗传调节有助于高度精确的记忆回忆。染色质修饰可能是神经生理学对“此时此地”经历的短暂感觉线索特征的反应的关键，并能在长期内重现。我们得出的结论是，感觉系统神经可塑性的表观遗传控制的功能是通过调节指导行为的行为相关线索的神经表征来调节长期记忆中保留的感觉信息的数量和类型。这在神经科学领域具有广泛的重要性，因为很少有情况下行为行为缺乏起始的感官体验。
The burgeoning field of neuroepigenetics has introduced chromatin modification as an important interface between experience and brain function. For example, epigenetic mechanisms like histone acetylation and DNA methylation operate throughout a lifetime to powerfully regulate gene expression in the brain that is required for experiences to be transformed into long-term memories. This review highlights emerging evidence from sensory models of memory that converge on the premise that epigenetic regulation of activity-dependent transcription in the sensory brain facilitates highly precise memory recall. Chromatin modifications may be key for neurophysiological responses to transient sensory cue features experienced in the “here and now” to be recapitulated over the long term. We conclude that the function of epigenetic control of sensory system neuroplasticity is to regulate the amount and type of sensory information retained in long-term memories by regulating neural representations of behaviorally relevant cues that guide behavior. This is of broad importance in the neuroscience field because there are few circumstances in which behavioral acts are devoid of an initiating sensory experience.
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影响因子：
2.7
作者：
White, Andre O.;Wood, Marcelo A.
通讯作者：
Wood, Marcelo A.
DOI：
10.1101/lm.036699.114
发表时间：
2015-04
期刊：
Learning & memory (Cold Spring Harbor, N.Y.)
影响因子：
--
作者：
Bowers ME;Xia B;Carreiro S;Ressler KJ
通讯作者：
Ressler KJ
影响因子：
3.1
作者：
Benoit J;Ayoub A;Rakic P
通讯作者：
Rakic P
影响因子：
1.7
作者：
Dietrich, Susanne;Hertrich, Ingo;Ackermann, Hermann
通讯作者：
Ackermann, Hermann
影响因子：
5.3
作者：
Baroncelli, Laura;Scali, Manuela;Sale, Alessandro
通讯作者：
Sale, Alessandro