Multifaceted Roles of Adipose Tissue-Derived Exosomes in Physiological and Pathological Conditions.
Multifaceted Roles of Adipose Tissue-Derived Exosomes in Physiological and Pathological Conditions.
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DOI：
10.3389/fphys.2021.669429
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发表时间：
2021
影响因子：
4
通讯作者：
Yuan L
中科院分区：
文献类型：
--
作者：
Liu Y;Wang C;Wei M;Yang G;Yuan L
脂肪组织在体内平衡和全身代谢中起重要作用，而肥胖与多种疾病有关。除了典型的激素、生长因子和细胞因子之外，外泌体已被确定在从脂肪组织到其他器官的信息传递中发挥重要作用。外泌体是由供体细胞分泌的纳米级膜囊泡，并将遗传信息转移到受体细胞，在受体细胞中释放封装的核酸和蛋白质。本文综述了近年来脂肪组织来源的外泌体的生物发生、分布及其对不同器官的生理和病理影响。此外，还讨论了外泌体作为治疗载体或药物的潜在意义。
Adipose tissue functions importantly in the bodily homeostasis and systemic metabolism, while obesity links to multiple disorders. Beyond the canonical hormones, growth factors and cytokines, exosomes have been identified to play important roles in transmission of information from adipose tissue to other organs. Exosomes are nanoscale membrane vesicles secreted by donor cells, and transfer the genetic information to the recipient cells where the encapsulated nucleic acids and proteins are released. In this review, we elaborate the recent advances in the biogenesis and profiling of adipose tissue derived exosomes, and their physiological and pathological effects on different organs. Moreover, the potential significance of the exosomes as therapeutic vehicles or drugs is also discussed.
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影响因子：
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作者：
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通讯作者：
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DOI：
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DOI：
10.1161/atvbaha.114.303029
发表时间：
2014-08
期刊：
Arteriosclerosis, thrombosis, and vascular biology
影响因子：
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作者：
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通讯作者：
Chang L