Transferrin receptor-targeted theranostic gold nanoparticles for photosensitizer delivery in brain tumors.
Transferrin receptor-targeted theranostic gold nanoparticles for photosensitizer delivery in brain tumors.
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DOI：
10.1039/c4nr04853a
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发表时间：
2015-02-07
期刊：
影响因子：
6.7
通讯作者：
Broome AM
中科院分区：
文献类型：
--
作者：
Dixit S;Novak T;Miller K;Zhu Y;Kenney ME;Broome AM
治疗药物通过血脑屏障（BBB）不仅效率低，而且对脑基质无特异性。这些是脑癌有效治疗的主要限制。设计了以转铁蛋白肽（Tfpep）为靶点的金纳米颗粒（Tfpep-Au NPs），并将其与非靶向的Au NPs进行了比较，以将光敏剂递送至脑肿瘤细胞系。过表达转铁蛋白受体（TfR）的人神经胶质瘤癌细胞系（LN 229和U87）的体外研究显示，与非靶向颗粒相比，靶向缀合物的细胞摄取显著增加。在用Tfpep靶向之后，从囊泡内的Tfpep-Au NPs簇递送的Pc 4。Pc 4在4小时内继续积累。我们的工作表明，转铁蛋白受体靶向的Au纳米粒子可能具有重要的治疗意义，提供脑肿瘤治疗和/或提供一个平台，非侵入性成像。
Therapeutic drug delivery across the blood-brain barrier (BBB) is not only inefficient, but also nonspecific to brain stroma. These are major limitations in the effective treatment of brain cancer. Transferrin peptide (Tfpep) targeted gold nanoparticles (Tfpep-Au NPs) loaded with the photodynamic pro-drug, Pc 4, have been designed and compared with untargeted Au NPs for delivery of the photosensitizer to brain cancer cell lines. In vitro studies of human glioma cancer lines (LN229 and U87) overexpressing the transferrin receptor (TfR) show a significant increase in cellular uptake for targeted conjugates as compared to un-targeted particles. Pc 4 delivered from Tfpep-Au NPs clusters within vesicles after targeting with the Tfpep. Pc 4 continues to accumulate over a 4 hour period. Our work suggests that TfR-targeted Au NPs may have important therapeutic implications for delivering brain tumor therapies and/or providing a platform for noninvasive imaging.
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影响因子：
2.4
作者：
Fernández-Nieves, A;Fernández-Barbero, A;de las Nieves, FJ
通讯作者：
de las Nieves, FJ
影响因子：
--
作者：
Faucher, Luc;Guay-Begin, Andree-Anne;Fortin, Marc-Andre
通讯作者：
Fortin, Marc-Andre
影响因子：
11.2
作者：
Hadjipanayis CG;Machaidze R;Kaluzova M;Wang L;Schuette AJ;Chen H;Wu X;Mao H
通讯作者：
Mao H
影响因子：
14
作者：
Dilnawaz, Fahima;Singh, Abhalaxmi;Sahoo, Sanjeeb Kumar
通讯作者：
Sahoo, Sanjeeb Kumar
影响因子：
15
作者：
Dhar, Shanta;Daniel, Weston L.;Giljohann, David A.;Mirkin, Chad A.;Lippard, Stephen J.
通讯作者：
Lippard, Stephen J.